Cortical dynamics in visual areas induced by the first use of multifocal contact lenses in presbyopes

Abstract

A common non-spectacle strategy to correct presbyopia is to provide simultaneous images with multifocal optical designs. Understanding the neuroadaptation mechanisms behind multifocal devices usage would have important clinical implications, such as predicting whether patients will be able to tolerate multifocal optics. The aim of this study was to evaluate the brain correlates during the initial wear of multifocal contact lenses (CLs) using high-density visual evoked potential (VEP) measures. Fifteen presbyopes (mean age 51.8 ± 2.6 years) who had previously not used multifocal CLs were enrolled. VEP measures were achieved while participants looked at arrays of 0.5 logMAR Sloan letters in three different optical conditions arranged with CLs: monofocal condition with the optical power appropriate for the distance viewing; multifocal correction with medium addition; and multifocal correction with low addition. An ANOVA for repeated measures showed that the amplitude of the C1 and N1 components significantly dropped with both multifocal low and medium addition CL conditions compared to monofocal CLs. The P1 and P2 components showed opposite behavior with an increase in amplitudes for multifocal compared to monofocal conditions. VEP data indicated that multifocal presbyopia corrections produce a loss of feedforward activity in the primary visual cortex that is compensated by extra feedback activity in extrastriate areas only, in both early and late visual processing.

Publication DOI: https://doi.org/10.1016/j.clae.2024.102137
Divisions: College of Health & Life Sciences
College of Health & Life Sciences > School of Optometry > Optometry
Aston University (General)
Funding Information: This study project entitled “Brain Adaptation to Multifocal contact lenses (BAM study)” was partly supported by an investigator lead unrestricted grant from Alcon Italia Spa. “The funding organization had no role in the design or conduct of this research.
Additional Information: Copyright © 2024 The Authors. Published by Elsevier Ltd on behalf of British Contact Lens Association. This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/)
Uncontrolled Keywords: Simultaneous images,Presbyopia,Visual-evoked potential (VEP),Neural adaptation,Multifocal contact lenses,Visual Cortex/physiopathology,Humans,Middle Aged,Male,Visual Acuity/physiology,Presbyopia/physiopathology,Contact Lenses,Evoked Potentials, Visual/physiology,Female
Publication ISSN: 1476-5411
Last Modified: 26 Nov 2024 08:15
Date Deposited: 04 Apr 2024 15:41
Full Text Link:
Related URLs: https://www.con ... 0020-1/fulltext (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2024-06-01
Published Online Date: 2024-03-13
Accepted Date: 2024-03-06
Authors: Zeri, Fabrizio (ORCID Profile 0000-0003-0529-555X)
Di Vizio, Assunta
Lucia, Stefania
Berchicci, Marika
Bianco, Valentina
Pitzalis, Sabrina
Tavazzi, Silvia
Naroo, Shehzad A. (ORCID Profile 0000-0002-6373-7187)
Di Russo, Francesco

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