Oxysterolsulfates in fluids, cells and tissues: how much do we know about their clinical significance, biological relevance and biophysical implications?


Oxysterol sulfates are emerging as key players in lipid homeostasis, inflammation and immunity. Despite this, knowledge on their basal levels in fluids, cells and tissues and any changes associated with age, gender and diet in health and disease; as well as their spatio-temporal distribution in cell membranes and organelles have been greatly hampered by the lack of commercially available pure synthetic standards. Expansion of the panel of pure oxysterol sulfates standards is pivotal to improve our understanding on the impact of oxysterol sulfates at the membrane level and their role in cellular events. While the clinical significance, biophysical implications and biological relevance of oxysterol sulfates in fluids, cells and tissues remains largely unknown, knowledge already gathered on the precursors of oxysterol sulfates (e.g. oxysterols and cholesterol sulfate) can be used to guide researchers on the most relevant aspects to search for when screening for oxysterol sulfates bioavailability in (patho)physiological conditions which are crucial in the design of biophysical and of cell-based assays. Herein, we provide a review on the brief knowledge involving oxysterol sulfate and an overview on the biophysical implications and biological relevance of oxysterols and cholesterol sulfate useful to redirect further investigations on the role of oxysterol sulfates in health and disease.

Publication DOI: https://doi.org/10.1042/EBC20230090
Divisions: College of Health & Life Sciences > Aston Medical School
Funding Information: A.R. acknowledges funding from FCT - Fundacao para a Ciencia e a Tecnologia, I.P., within Norma Transitoria - DL 57/2016/CP1346/CT0006. I.H.K.D. would like to acknowledge the funding support by Alzheimer’s Association [grant number AARGD-22-926459]. This
Additional Information: Copyright © 2024 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY: https://creativecommons.org/licenses/by/4.0/).
Publication ISSN: 1744-1358
Last Modified: 21 May 2024 07:18
Date Deposited: 28 Mar 2024 14:48
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Related URLs: https://portlan ... and-tissues-how (Publisher URL)
PURE Output Type: Review article
Published Date: 2024-03-28
Published Online Date: 2024-03-28
Accepted Date: 2024-03-12
Authors: Reis, Ana
Dias, Irundika (ORCID Profile 0000-0002-6620-8221)



Version: Published Version

License: Creative Commons Attribution

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