The Mechanical Properties of the Spinal Cord: A Systematic Review

Abstract

BACKGROUND CONTENT: Spinal cord compression is a source of pathology routinely seen in clinical practice. However, there remain unanswered questions surrounding both the understanding of pathogenesis and the best method of treatment. This arises from limited real-life testing of the mechanical properties of the spinal cord, either through cadaveric human specimens or animal testing, both of which suffer from methodological, as well as ethical, issues. PURPOSE: To conduct a review of the literature on the mechanical properties of the spinal cord. STUDY DESIGN/SETTING: A systematic review of the literature on the mechanical properties of the spinal cord is undertaken. PATIENT SAMPLE: All literature reporting the testing of the mechanical properties of the spinal cord. OUTCOME MEASURES: Reported physiological mechanical properties of the spinal cord. METHODS: The methodological quality of the studies has been assessed within the ARRIVE guidelines using the CAMARADES framework and SYRCLE's risk of bias tool. This paper details the methodologies and results of the reported testing. RESULTS: We show that (1) the research quality of previous work does not follow published guidelines on animal treatment or risk of bias, (2) no standard protocol has been employed for sample preparation or mechanical testing, (3) this leads to a wide distribution of results for the tested mechanical properties, not applicable to the living human or animal, and (4) animal testing is not a good proxy for human application. CONCLUSIONS: The findings summarize the sum of current knowledge inherent to the mechanical properties of the spinal cord and may contribute to the development of a physical model which is applicable to the living human for analysis and testing in a controlled and repeatable fashion. Such a model would be the basis for further clinical research to improve outcomes from spinal cord compression.

Publication DOI: https://doi.org/10.1016/j.spinee.2024.02.022
Divisions: College of Engineering & Physical Sciences > Engineering for Health
College of Engineering & Physical Sciences > School of Engineering and Technology > Mechanical, Biomedical & Design
Aston University (General)
Funding Information: Author disclosures: MS: Nothing to disclose. MOR: Nothing to disclose. ET: Nothing to disclose. JBRGS: Nothing to disclose. AG: Grants: NIHR (H, Paid directly to institution/employer), ORUK/BSS/BASS (E, Paid directly to institution/employer), Innovate UK
Additional Information: Copyright © 2024 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords: Mechanical properties,Mechanical testing,Spinal cord,Spine,Systematic review,Biomechanical Phenomena,Animals,Humans,Spinal Cord Compression,Spinal Cord/physiology,Clinical Neurology,Surgery,Orthopedics and Sports Medicine
Publication ISSN: 1432-0932
Last Modified: 23 Dec 2024 09:00
Date Deposited: 14 Mar 2024 16:40
Full Text Link:
Related URLs: https://www.sci ... 529943024001050 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Review article
Published Date: 2024-03-01
Published Online Date: 2024-03-01
Accepted Date: 2024-02-25
Authors: Stanners, Megan
O'Riordan, Marguerite
Theodosiou, Eirini (ORCID Profile 0000-0001-7068-4434)
Souppez, Jean-Baptiste R. G. (ORCID Profile 0000-0003-0217-5819)
Gardner, Adrian

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Version: Accepted Version

Access Restriction: Restricted to Repository staff only until 1 March 2025.

License: Creative Commons Attribution Non-commercial No Derivatives


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