A Novel Biosensor for the Detection of Glucose Concentration Using the Dual-Peak Long Period Grating in the Near- to Mid-Infrared


In this article, we demonstrate an improved efficient fibre sensor with a high sensitivity to measure glucose concentrations in the physiological range of human beings, operating in a broad spectral bandwidth from the near- to mid-infrared. The sensor consists of a dual-peak long period grating (DPLPG) with a period of 150 μm inscribed in an optical fibre with a diameter of 80 μm. The investigation of sensing for refractive index results in a sensitivity of ~-885.7 nm/refractive index unit (RIU) and ~2008.6 nm/RIU in the range of 1.30-1.44. The glucose measurement is achieved by the immobilisation of a layer of enzyme of glucose oxidase (GOD) onto the fibre surface for the selective enhancement of sensitivity for glucose. The sensor can measure glucose concentrations with a maximum sensitivity of -36.25 nm/(mg/mL) in the range of 0.1-3.0 mg/mL. To the best of our knowledge, this is the highest sensitivity ever achieved for a measurement of glucose with a long period grating-based sensor, indicating its potential for many applications including pharmaceutical, biomedical and food industries.

Publication DOI: https://doi.org/10.3390/s24041247
Divisions: College of Engineering & Physical Sciences > Aston Institute of Photonics Technology (AIPT)
College of Engineering & Physical Sciences
Funding Information: This research was funded by the UK Royal Society Newton Advanced Fellowship programme (NAF/R1/191072) and European Union Horizon 2020 Research and Innovation Staff Exchange (RISE) programme (No. 872049, IPN-Bio).
Additional Information: Copyright © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)
Uncontrolled Keywords: dual-peak long period gratings,enzyme immobilisation,glucose sensing,Analytical Chemistry,Information Systems,Instrumentation,Atomic and Molecular Physics, and Optics,Electrical and Electronic Engineering,Biochemistry
Publication ISSN: 1424-8220
Data Access Statement: The data are available on request.
Last Modified: 18 Jul 2024 07:31
Date Deposited: 05 Mar 2024 18:10
Full Text Link:
Related URLs: https://www.mdp ... -8220/24/4/1247 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2024-02-29
Published Online Date: 2024-02-15
Accepted Date: 2024-02-09
Authors: Sahoo, Namita
Sun, Bing
Tan, Yidong
Zhou, Kaiming (ORCID Profile 0000-0002-6011-1912)
Zhang, Lin (ORCID Profile 0000-0002-1691-5577)



Version: Published Version

License: Creative Commons Attribution

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