Effects of carotenoids on mitochondrial dysfunction


Oxidative stress, an imbalance between pro-oxidant and antioxidant status, favouring the pro-oxidant state is a result of increased production of reactive oxygen species (ROS) or inadequate antioxidant protection. ROS are produced through several mechanisms in cells including during mitochondrial oxidative phosphorylation. Increased mitochondrial-derived ROS are associated with mitochondrial dysfunction, an early event in age-related diseases such as Alzheimer's diseases (ADs) and in metabolic disorders including diabetes. AD post-mortem investigations of affected brain regions have shown the accumulation of oxidative damage to macromolecules, and oxidative stress has been considered an important contributor to disease pathology. An increase in oxidative stress, which leads to increased levels of superoxide, hydrogen peroxide and other ROS in a potentially vicious cycle is both causative and a consequence of mitochondrial dysfunction. Mitochondrial dysfunction may be ameliorated by molecules with antioxidant capacities that accumulate in mitochondria such as carotenoids. However, the role of carotenoids in mitigating mitochondrial dysfunction is not fully understood. A better understanding of the role of antioxidants in mitochondrial function is a promising lead towards the development of novel and effective treatment strategies for age-related diseases. This review evaluates and summarises some of the latest developments and insights into the effects of carotenoids on mitochondrial dysfunction with a focus on the antioxidant properties of carotenoids. The mitochondria-protective role of carotenoids may be key in therapeutic strategies and targeting the mitochondria ROS is emerging in drug development for age-related diseases.

Publication DOI: https://doi.org/10.1042/BST20230193
Divisions: College of Health & Life Sciences > Aston Medical School
Funding Information: I.H.K.D. would like to acknowledge the funding support by Alzheimer’s Association grant AARGD-22-926459. H.R.G. is funded by the EU Horizon Europe FET Open Programme, NeutroCure.
Additional Information: Copyright © 2024 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
Uncontrolled Keywords: astaxanthin,carotenoids,mitochondria,oxidative stress,reactive oxygen species
Publication ISSN: 1470-8752
Last Modified: 14 May 2024 07:31
Date Deposited: 22 Feb 2024 13:51
Full Text Link:
Related URLs: https://portlan ... n-mitochondrial (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Review article
Published Date: 2024-02-28
Published Online Date: 2024-02-22
Accepted Date: 2024-02-08
Authors: Ademowo, Opeyemi Stella
Oyebode, Olubukola
Edward, Roshita
Conway, Myra E.
Griffiths, Helen R
Dias, Irundika (ORCID Profile 0000-0002-6620-8221)



Version: Published Version

License: Creative Commons Attribution

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