Krasian, Tharnthip, Punyodom, Winita, Molloy, Robert, Topham, Paul, Tighe, Brian, Mahomed, Anisa, Chaiwarit, Tanpong, Panraksa, Pattaraporn, Rachtanapun, Pornchai, Jantanasakulwong, Kittisak and Worajittiphon, Patnarin (2024). Low cytotoxicity, antibacterial property, and curcumin delivery performance of toughness-enhanced electrospun composite membranes based on poly(lactic acid) and MAX phase (Ti3AlC2). International Journal of Biological Macromolecules, 262 ,
Abstract
MXenes, synthesized from their precursor MAX phases, have been extensively researched as additives to enhance the drug delivery performance of polymer matrices, whereas there is a limited number of previous reports on the use of MAX phases themselves for such applications. The use of MAX phases can exclude the complicated synthesis procedure and lessen resultant production and environmental costs required to convert MAX phases to MXenes. Herein, electrospun membranes of poly(lactic acid) (PLA) and a MAX phase (Ti3AlC2) have been fabricated for curcumin delivery. The composite membrane exhibits significantly higher toughness (8.82 MJ m-3) than the plasticized PLA membrane (0.63 MJ m-3) with low cytotoxicity, supporting proliferation of mouse fibroblast L929 cells. The curcumin-loaded composite membrane exhibits high water vapor transmission (~7350 g m-2 day-1), porosity (~85 %), water wettability, and antibacterial properties against E. coli and S. aureus. Seven-day curcumin release is enhanced from 45 % (PLA) to 67 % (composite) due to curcumin diffusion from the polymer fibers and MAX phase surface that contributes to overall increased curcumin adsorption and release sites. This work demonstrates the potential of the MAX phase to enhance both properties and curcumin delivery, promising for other eco-friendly systems for sustainable drug delivery applications.
Publication DOI: | https://doi.org/10.1016/j.ijbiomac.2024.129967 |
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Divisions: | College of Engineering & Physical Sciences > Aston Institute of Materials Research (AIMR) College of Engineering & Physical Sciences > Aston Advanced Materials College of Engineering & Physical Sciences > Engineering for Health College of Engineering & Physical Sciences > Aston Polymer Research Group College of Engineering & Physical Sciences College of Engineering & Physical Sciences > School of Infrastructure and Sustainable Engineering > Chemical Engineering & Applied Chemistry |
Funding Information: | Fundamental Fund 2023, Chiang Mai University European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No. 871650 (MEDIPOL) |
Additional Information: | Copyright © 2023, Elsevier. This accepted manuscript version is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Uncontrolled Keywords: | Poly(lactic acid),MAX phase,Electrospun membrane,Drug delivery,Curcumin,Low cytotoxicity |
Publication ISSN: | 0141-8130 |
Last Modified: | 04 Oct 2024 16:02 |
Date Deposited: | 07 Feb 2024 14:17 |
Full Text Link: | |
Related URLs: |
https://www.sci ... 7700?via%3Dihub
(Publisher URL) http://www.scop ... tnerID=8YFLogxK (Scopus URL) |
PURE Output Type: | Article |
Published Date: | 2024-03 |
Published Online Date: | 2024-02-03 |
Accepted Date: | 2024-02-02 |
Authors: |
Krasian, Tharnthip
Punyodom, Winita Molloy, Robert Topham, Paul ( 0000-0003-4152-6976) Tighe, Brian ( 0000-0001-9601-8501) Mahomed, Anisa ( 0000-0002-3719-7543) Chaiwarit, Tanpong Panraksa, Pattaraporn Rachtanapun, Pornchai Jantanasakulwong, Kittisak Worajittiphon, Patnarin |
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