Low cytotoxicity, antibacterial property, and curcumin delivery performance of toughness-enhanced electrospun composite membranes based on poly(lactic acid) and MAX phase (Ti3AlC2)


MXenes, synthesized from their precursor MAX phases, have been extensively researched as additives to enhance the drug delivery performance of polymer matrices, whereas there is a limited number of previous reports on the use of MAX phases themselves for such applications. The use of MAX phases can exclude the complicated synthesis procedure and lessen resultant production and environmental costs required to convert MAX phases to MXenes. Herein, electrospun membranes of poly(lactic acid) (PLA) and a MAX phase (Ti3AlC2) have been fabricated for curcumin delivery. The composite membrane exhibits significantly higher toughness (8.82 MJ m-3) than the plasticized PLA membrane (0.63 MJ m-3) with low cytotoxicity, supporting proliferation of mouse fibroblast L929 cells. The curcumin-loaded composite membrane exhibits high water vapor transmission (~7350 g m-2 day-1), porosity (~85 %), water wettability, and antibacterial properties against E. coli and S. aureus. Seven-day curcumin release is enhanced from 45 % (PLA) to 67 % (composite) due to curcumin diffusion from the polymer fibers and MAX phase surface that contributes to overall increased curcumin adsorption and release sites. This work demonstrates the potential of the MAX phase to enhance both properties and curcumin delivery, promising for other eco-friendly systems for sustainable drug delivery applications.

Publication DOI: https://doi.org/10.1016/j.ijbiomac.2024.129967
Divisions: College of Engineering & Physical Sciences > Aston Institute of Materials Research (AIMR)
College of Engineering & Physical Sciences > Aston Advanced Materials
College of Engineering & Physical Sciences > Engineering for Health
College of Engineering & Physical Sciences > Aston Polymer Research Group
College of Engineering & Physical Sciences
College of Engineering & Physical Sciences > School of Infrastructure and Sustainable Engineering > Chemical Engineering & Applied Chemistry
Funding Information: Fundamental Fund 2023, Chiang Mai University European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No. 871650 (MEDIPOL)
Additional Information: Copyright © 2023, Elsevier. This accepted manuscript version is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International https://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords: Poly(lactic acid),MAX phase,Electrospun membrane,Drug delivery,Curcumin,Low cytotoxicity
Publication ISSN: 0141-8130
Last Modified: 09 Jul 2024 07:40
Date Deposited: 07 Feb 2024 14:17
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Related URLs: https://www.sci ... 7700?via%3Dihub (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2024-03
Published Online Date: 2024-02-03
Accepted Date: 2024-02-02
Authors: Krasian, Tharnthip
Punyodom, Winita
Molloy, Robert
Topham, Paul (ORCID Profile 0000-0003-4152-6976)
Tighe, Brian (ORCID Profile 0000-0001-9601-8501)
Mahomed, Anisa (ORCID Profile 0000-0002-3719-7543)
Chaiwarit, Tanpong
Panraksa, Pattaraporn
Rachtanapun, Pornchai
Jantanasakulwong, Kittisak
Worajittiphon, Patnarin



Version: Accepted Version

Access Restriction: Restricted to Repository staff only until 3 February 2025.

License: Creative Commons Attribution Non-commercial No Derivatives

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