Epidemiology and Financial Burden of Adult Chronic Hypoparathyroidism

Abstract

Chronic hypoparathyroidism is characterized by low serum calcium, increased serum phosphorus, and inappropriately low or decreased serum parathyroid hormone. This rare disorder is associated with a variety of complications. The prevalence, incidence, mortality, financial burden, and epidemiology of complications of this disorder are not well understood. This narrative review summarizes current information on the epidemiology and complications of chronic hypoparathyroidism. The reported prevalence of chronic hypoparathyroidism ranges from 6.4–37/100,000, and the incidence is reported to be 0.8–2.3/100,000/year. Mortality is not increased in studies from Denmark or South Korea but was increased in studies from Scotland and Sweden. The financial burden of this disorder is substantial because of increased health care resource utilization in two studies but not well quantitated. Recognized complications include hypercalciuria, nephrocalcinosis, kidney stones, and chronic kidney disease; low bone turnover and possibly upper extremity fractures; cardiac and vascular calcifications; basal ganglia calcifications, cataracts, infections, neuropsychiatric complications, and difficulties with pregnancy. This review concludes that chronic hypoparathyroidism is a rare disorder associated with significant morbidity that may not increase overall mortality but is associated with a substantial financial burden.

Publication DOI: https://doi.org/10.1002/jbmr.4675
Divisions: College of Health & Life Sciences > Aston Medical School
Additional Information: Copyright © 2022, The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Uncontrolled Keywords: Complications,Epidemiology,Financial Burden,Hypoparathyroidism,Prevalence
Publication ISSN: 1523-4681
Last Modified: 02 Dec 2024 09:03
Date Deposited: 30 Jan 2024 17:56
Full Text Link:
Related URLs: https://academi ... 12/2602/7499989 (Publisher URL)
PURE Output Type: Article
Published Date: 2022-12-01
Published Online Date: 2022-08-11
Accepted Date: 2022-08-07
Authors: Bjornsdottir, Sigridur
Ing, Steven
Mitchell, Deborah M.
Sikjaer, Tanja
Underbjerg, Line
Hassan-Smith, Zaki (ORCID Profile 0000-0002-8387-3039)
Sfeir, Jad
Gittoes, Neil J.
Clarke, Bart L.

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