Real-time laser speckle contrast imaging for intraoperative neurovascular blood flow assessment: animal experimental study

Abstract

The use of various blood flow control methods in neurovascular interventions is crucial for reducing postoperative complications. Neurosurgeons worldwide use different methods, such as contact Dopplerography, intraoperative indocyanine videoangiography (ICG) video angiography, fluorescein angiography, flowmetry, intraoperative angiography, and direct angiography. However, there is no noninvasive method that can assess the presence of blood flow in the vessels of the brain without the introduction of fluorescent substances throughout the intervention. The real-time laser-speckle contrast imaging (LSCI) method was studied for its effectiveness in controlling blood flow in standard cerebrovascular surgery cases in rat common carotid arteries, such as proximal occlusion, trapping, reperfusion, anastomosis, and intraoperative vessel thrombosis. The real-time LSCI method is a promising method for use in neurosurgical practice. This approach allows timely diagnosis of intraoperative disturbance of blood flow in vessels in cases of clip occlusion or thrombosis. Additionally, LSCI allows us to reliably confirm the functioning of the anastomosis and reperfusion after removal of the clips and thrombolysis in real time. An unresolved limitation of the method is noise from movements, but this does not reduce the value of the method. Additional research is required to improve the quality of the data obtained.

Publication DOI: https://doi.org/10.1038/s41598-023-51022-2
Divisions: College of Engineering & Physical Sciences > School of Engineering and Technology > Mechanical, Biomedical & Design
College of Engineering & Physical Sciences > Engineering for Health
College of Engineering & Physical Sciences
Aston University (General)
Funding Information: The research reported in this publication was supported by the Burdenko Neurosurgical Center. The experiment was carried out with the support of a Russian Science Foundation (Project No. 22-65-00096). The data processing part of the project was supported
Additional Information: Copyright © 2024, The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/. Data availability: The datasets generated and/or analysed during the current study are available in the repository, https://1drv. ms/f/s!AmNlRMtkMjGrgtZv-54XcCQCcq55MQ?e=cBlHa2
Uncontrolled Keywords: Animals,Coloring Agents,Fluorescein Angiography,Indocyanine Green,Laser Speckle Contrast Imaging,Rats,Thrombosis
Publication ISSN: 2045-2322
Last Modified: 02 Dec 2024 09:03
Date Deposited: 19 Jan 2024 15:18
Full Text Link:
Related URLs: https://www.nat ... 598-023-51022-2 (Publisher URL)
https://1drv. m ... cq55MQ?e=cBlHa2 (Related URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2024-01-19
Published Online Date: 2024-01-19
Accepted Date: 2024-01-10
Authors: Konovalov, Anton N
Grebenev, Fyodor V
Stavtsev, Dmitry
Kozlov, Igor O.
Vadim, Gadjiagaev
Piavchenko, Gennadii A.
Telyshev, Dmitry V.
Gerasimenko, Alexander Yu.
Meglinski, Igor (ORCID Profile 0000-0002-7613-8191)
Zalogin, Savely
Artemyev, Anton
Golodnev, Grigorii
Shumeiko, Tatiana
Eliava, Shalva

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