Englezou, Christina, Nazeer, Kabir K. and Rajabally, Yusuf A. (2023). Impact of social-functioning and sleep on quality of life in chronic inflammatory demyelinating polyneuropathy. Clinical Neurology and Neurosurgery, 234 ,
Abstract
Introduction /Aims The impact of impairment of social functioning and sleep on health-related quality of life (HR-QoL), is unknown in chronic inflammatory demyelinating polyneuropathy (CIDP). The value of the Chronic Acquired Polyneuropathy Patient-Reported Index (CAP-PRI) to identify potential social functioning and sleep issues is equally unknown. Methods We performed a cross-sectional evaluation of social functioning and sleep using the “Scales for Outcomes in Parkinson’s Disease” (SCOPA) in 40 subjects with clinically-stable CIDP through a structured questionnaire. We assessed HR-QoL through the CAP-PRI. Disability was evaluated through the Overall Neuropathy Limitation Score (ONLS). Results SCOPA social functioning scores were impaired at least “a little” per averaged item in >50% of subjects, and at least “quite a bit” per averaged item in >20%. Most affected items were (i) difficulty with work/household/other chores (ii) difficulties with hobbies/sport/leisure activities. SCOPA sleep sub-scores indicated at least “a little concern” for night-time sleep in nearly 50% of subjects. Abnormal sleep timing was rare. Associations were found between both SCOPA social-functioning and SCOPA sleep scores and the CAP-PRI. Linear regression demonstrated the SCOPA social-functioning score was independently associated with the CAP-PRI. The CAP-PRI showed high association with disability scores, good internal consistency, absence of ceiling effect, absence of significant floor-effect, and good criteria-related as well as construct-related validity. Discussion Social functioning and night-time sleep are frequently affected in CIDP and impact on HR-QoL. In contrast to traditional disability scales, the CAP-PRI additionally allows adequately capturing these impairments and may represent an adequate holistic outcome measure.
Publication DOI: | https://doi.org/10.1016/j.clineuro.2023.108017 |
---|---|
Divisions: | College of Health & Life Sciences |
Additional Information: | © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/). |
Uncontrolled Keywords: | Chronic inflammatory demyelinating polyneuropathy,Immunoglobulins,Outcome measures,Response,Treatment,Clinical Neurology,Surgery |
Publication ISSN: | 0303-8467 |
Last Modified: | 02 Dec 2024 09:01 |
Date Deposited: | 09 Jan 2024 12:59 |
Full Text Link: | |
Related URLs: |
https://www.sci ... 30384672300433X
(Publisher URL) http://www.scop ... tnerID=8YFLogxK (Scopus URL) |
PURE Output Type: | Article |
Published Date: | 2023-11 |
Published Online Date: | 2023-10-17 |
Accepted Date: | 2023-10-15 |
Authors: |
Englezou, Christina
Nazeer, Kabir K. Rajabally, Yusuf A. |
Download
Version: Published Version
License: Creative Commons Attribution Non-commercial No Derivatives
| Preview