Impact of social-functioning and sleep on quality of life in chronic inflammatory demyelinating polyneuropathy

Abstract

Introduction /Aims The impact of impairment of social functioning and sleep on health-related quality of life (HR-QoL), is unknown in chronic inflammatory demyelinating polyneuropathy (CIDP). The value of the Chronic Acquired Polyneuropathy Patient-Reported Index (CAP-PRI) to identify potential social functioning and sleep issues is equally unknown. Methods We performed a cross-sectional evaluation of social functioning and sleep using the “Scales for Outcomes in Parkinson’s Disease” (SCOPA) in 40 subjects with clinically-stable CIDP through a structured questionnaire. We assessed HR-QoL through the CAP-PRI. Disability was evaluated through the Overall Neuropathy Limitation Score (ONLS). Results SCOPA social functioning scores were impaired at least “a little” per averaged item in >50% of subjects, and at least “quite a bit” per averaged item in >20%. Most affected items were (i) difficulty with work/household/other chores (ii) difficulties with hobbies/sport/leisure activities. SCOPA sleep sub-scores indicated at least “a little concern” for night-time sleep in nearly 50% of subjects. Abnormal sleep timing was rare. Associations were found between both SCOPA social-functioning and SCOPA sleep scores and the CAP-PRI. Linear regression demonstrated the SCOPA social-functioning score was independently associated with the CAP-PRI. The CAP-PRI showed high association with disability scores, good internal consistency, absence of ceiling effect, absence of significant floor-effect, and good criteria-related as well as construct-related validity. Discussion Social functioning and night-time sleep are frequently affected in CIDP and impact on HR-QoL. In contrast to traditional disability scales, the CAP-PRI additionally allows adequately capturing these impairments and may represent an adequate holistic outcome measure.

Publication DOI: https://doi.org/10.1016/j.clineuro.2023.108017
Divisions: College of Health & Life Sciences
Additional Information: © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).
Uncontrolled Keywords: Chronic inflammatory demyelinating polyneuropathy,Immunoglobulins,Outcome measures,Response,Treatment,Clinical Neurology,Surgery
Publication ISSN: 0303-8467
Last Modified: 02 Dec 2024 09:01
Date Deposited: 09 Jan 2024 12:59
Full Text Link:
Related URLs: https://www.sci ... 30384672300433X (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2023-11
Published Online Date: 2023-10-17
Accepted Date: 2023-10-15
Authors: Englezou, Christina
Nazeer, Kabir K.
Rajabally, Yusuf A.

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