Dremin, Viktor, Zharkikh, Elena V., Lopushenko, Ivan, Marcinkevics, Zbignevs, Bykov, Alexander V. and Meglinski, Igor (2024). Incremental residual polarization caused by aging in human skin. Journal of Biomedical Optics, 29 (5),
Abstract
Significance: The study of the effect of aging on the optical properties of biological tissues, in particular polarization, is important in the development of new diagnostic approaches. Aim: This work aims to provide a comprehensive analysis of the factors and mechanisms that contribute to the alteration of skin polarization properties caused by aging, using polarization-sensitive hyperspectral imaging measurements and Monte Carlo simulation. Approach: Our investigation involved both experimental studies of in vivo human skin of volunteers of different ages and computational modeling that accounted for changes in the absorption and scattering properties of the skin model. Specifically, we analyzed alterations in the degree of linear polarization (DOLP) to better understand the impact of aging on skin polarization properties. Results: A statistically significant increase in the DOLP was found for the elderly group. At the same time, there was no correlation between changes in polarization and the calculated blood volume fraction parameter for different ages. According to the simulation results, it was also found that a change in the scattering properties of biological tissues has a more significant effect on the change in polarizing light compared to the change in absorption. Conclusions: The results of the work prove that the sensitivity of polarization imaging to age- or pathological-related skin changes may be primarily due to changes in scattering, which in turn is associated with changes in the collagen fibers of the dermis. The proposed technique shows promise for in vivo non-invasive real-time assessment of age-associated skin changes and can also be extended to monitor changes associated with the development of age-related pathologies.
Publication DOI: | https://doi.org/10.1117/1.JBO.29.5.052912 |
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Divisions: | College of Engineering & Physical Sciences > Aston Institute of Photonics Technology (AIPT) College of Engineering & Physical Sciences College of Engineering & Physical Sciences > School of Engineering and Technology > Mechanical, Biomedical & Design College of Health & Life Sciences College of Engineering & Physical Sciences > Engineering for Health Aston University (General) |
Funding Information: | The authors acknowledge the support of the Academy of Finland (Grant Nos. 314369, 325097, and 347876) and the European Union’s Horizon 2020 Research and Innovative Program (ATTRACT II META-HiLight Project No. 101004462). E.Z. acknowledges the support of t |
Additional Information: | Copyright © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. [DOI: 10.1117/1.JBO.29.5.052912] |
Uncontrolled Keywords: | polarization,hyperspectral imaging,human skin,Monte carlo simulation |
Publication ISSN: | 1560-2281 |
Last Modified: | 25 Nov 2024 17:43 |
Date Deposited: | 20 Nov 2023 14:44 |
Full Text Link: | |
Related URLs: |
https://www.spi ... 2912.full?SSO=1
(Publisher URL) http://www.scop ... tnerID=8YFLogxK (Scopus URL) |
PURE Output Type: | Article |
Published Date: | 2024-05 |
Published Online Date: | 2023-11-14 |
Accepted Date: | 2023-10-19 |
Authors: |
Dremin, Viktor
(
0000-0001-6974-3505)
Zharkikh, Elena V. Lopushenko, Ivan Marcinkevics, Zbignevs Bykov, Alexander V. Meglinski, Igor ( 0000-0002-7613-8191) |