Ultraviolet Light Responsive N‐Nitroso Polymers for Antibacterial Nitric Oxide Delivery

Abstract

This study investigates the incorporation of active secondary amine moieties into the polymer backbone by co-polymerizing 2,4,6-tris(chloromethyl)-mesitylene with three diamines, namely 1,4-diaminobutane, m-phenylenediamine, and p-phenylenediamine. This process results in the stabilization of the amine moieties and the subsequently introduced nitroso groups. Charging bioactive nitric oxide (NO) into the polymers is accomplished by converting the amine moieties into N-nitroso groups. The ability of the polymers to store and release NO depends on their structures, particularly the amount of incorporated active secondary amines. With grafting photosensitive N-nitroso groups into the polymers, the derived NO@polymers exhibit photoresponsivity. NO release is completely regulated by adjusting UV light irradiation. These resulting polymeric NO donors demonstrate remarkable bactericidal and bacteriostatic activity, effectively eradicating E. coli bacteria and inhibiting their growth. The findings from this study hold promising implications for combining NO delivery with phototherapy in various medical applications.

Publication DOI: https://doi.org/10.1002/marc.202300473
Divisions: College of Engineering & Physical Sciences > School of Infrastructure and Sustainable Engineering > Chemical Engineering & Applied Chemistry
College of Engineering & Physical Sciences
College of Engineering & Physical Sciences > Aston Institute of Materials Research (AIMR)
Aston University (General)
Additional Information: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Uncontrolled Keywords: Materials Chemistry,Polymers and Plastics,Organic Chemistry,copolymers,nitric oxide,light irradiation,photoresponsivity,antibacterial materials,Materials Chemistry,Polymers and Plastics,Organic Chemistry
Publication ISSN: 1022-1336
Last Modified: 02 Dec 2024 09:00
Date Deposited: 02 Oct 2023 09:29
Full Text Link:
Related URLs: https://onlinel ... /marc.202300473 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2023-11
Published Online Date: 2023-09-20
Accepted Date: 2023-09-17
Submitted Date: 2023-08-05
Authors: Qiu, Yusheng
Zhao, Taoran
Lu, Xin
Yuan, Qingchun (ORCID Profile 0000-0001-5982-3819)
Gregg, Sharon
Nze, René‐Ponce
Xiao, Bo

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