Inhibitory control in children with agenesis of the corpus callosum compared with typically developing children


OBJECTIVES: The developmental absence (agenesis) of the corpus callosum (AgCC) is a congenital brain malformation associated with risk for a range of neuropsychological difficulties. Inhibitory control outcomes, including interference control and response inhibition, in children with AgCC are unclear. This study examined interference control and response inhibition: 1) in children with AgCC compared with typically developing (TD) children, 2) in children with different anatomical features of AgCC (complete vs. partial, isolated vs. complex), and 3) associations with white matter volume and microstructure of the anterior (AC) and posterior commissures (PC) and any remnant corpus callosum (CC). METHODS: Participants were 27 children with AgCC and 32 TD children 8-16 years who completed inhibitory control assessments and brain MRI to define AgCC anatomical features and measure white matter volume and microstructure. RESULTS: The AgCC cohort had poorer performance and higher rates of below average performance on inhibitory control measures than TD children. Children with complex AgCC had poorer response inhibition performance than children with isolated AgCC. While not statistically significant, there were select medium to large effect sizes for better inhibitory control associated with greater volume and microstructure of the AC and PC, and with reduced volume and microstructure of the remnant CC in partial AgCC. CONCLUSIONS: This study provides evidence of inhibitory control difficulties in children with AgCC. While the sample was small, the study found preliminary evidence that the AC ( f 2=.18) and PC ( f 2=.30) may play a compensatory role for inhibitory control outcomes in the absence of the CC.

Publication DOI:
Divisions: College of Health & Life Sciences > School of Psychology
College of Health & Life Sciences > Aston Institute of Health & Neurodevelopment (AIHN)
Additional Information: This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (, which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © INS. Published by Cambridge University Press, 2023
Uncontrolled Keywords: executive functions,callosal agenesis,interference control,response inhibition,children,inhibition
Publication ISSN: 1469-7661
Last Modified: 23 May 2024 07:22
Date Deposited: 19 Sep 2023 12:15
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Related URLs: ... 601D99AC3FCD1F7 (Publisher URL)
PURE Output Type: Article
Published Date: 2023-04-14
Published Online Date: 2023-04-14
Accepted Date: 2023-01-23
Authors: Soon, Emilyn
Siffredi, Vanessa
Anderson, Peter J
Anderson, Vicki A
McIlroy, Alissandra
Leventer, Richard J
Wood, Amanda G (ORCID Profile 0000-0002-1537-6858)
Spencer-Smith, Megan M



Version: Published Version

License: Creative Commons Attribution

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