Real-time imaging of human cortical activity evoked by painful esophageal stimulation


Background & Aims: Current models of visceral pain processing derived from metabolic brain imaging techniques fail to differentiate between exogenous (stimulus-dependent) and endogenous (non-stimulus-specific) neural activity. The aim of this study was to determine the spatiotemporal correlates of exogenous neural activity evoked by painful esophageal stimulation. Methods: In 16 healthy subjects (8 men; mean age, 30.2 ± 2.2 years), we recorded magnetoencephalographic responses to 2 runs of 50 painful esophageal electrical stimuli originating from 8 brain subregions. Subsequently, 11 subjects (6 men; mean age, 31.2 ± 1.8 years) had esophageal cortical evoked potentials recorded on a separate occasion by using similar experimental parameters. Results: Earliest cortical activity (P1) was recorded in parallel in the primary/secondary somatosensory cortex and posterior insula (∼85 ms). Significantly later activity was seen in the anterior insula (∼103 ms) and cingulate cortex (∼106 ms; P = .0001). There was no difference between the P1 latency for magnetoencephalography and cortical evoked potential (P = .16); however, neural activity recorded with cortical evoked potential was longer than with magnetoencephalography (P = .001). No sex differences were seen for psychophysical or neurophysiological measures. Conclusions: This study shows that exogenous cortical neural activity evoked by experimental esophageal pain is processed simultaneously in somatosensory and posterior insula regions. Activity in the anterior insula and cingulate - brain regions that process the affective aspects of esophageal pain - occurs significantly later than in the somatosensory regions, and no sex differences were observed with this experimental paradigm. Cortical evoked potential reflects the summation of cortical activity from these brain regions and has sufficient temporal resolution to separate exogenous and endogenous neural activity. © 2005 by the American Gastroenterological Association.

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Divisions: College of Health & Life Sciences > School of Psychology
College of Health & Life Sciences
?? NABC ??
College of Health & Life Sciences > School of Optometry > Optometry
Uncontrolled Keywords: visceral pain processing,metabolic brain imaging techniques,exogenous neural activity,endogenous neural activity,spatiotemporal correlates,painful esophageal stimulation,Gastroenterology
Publication ISSN: 1528-0012
Last Modified: 23 Oct 2019 10:23
Date Deposited: 07 Oct 2010 14:59
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
Published Date: 2005-03
Authors: Hobson, Anthony R.
Furlong, Paul L.
Worthen, Sian F. (ORCID Profile 0000-0003-1980-0932)
Hillebrand, Arjan
Barnes, Gareth R.
Singh, Krish D.
Aziz, Qasim


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