Nanocellulose-based porous materials: Regulation and pathway to commercialization in regenerative medicine


We review the recent progress that have led to the development of porous materials based on cellulose nanostructures found in plants and other resources. In light of the properties that emerge from the chemistry, shape and structural control, we discuss some of the most promising uses of a plant-based material, nanocellulose, in regenerative medicine. Following a brief discussion about the fundamental aspects of self-assembly of nanocellulose precursors, we review the key strategies needed for material synthesis and to adjust the architecture of the materials (using three-dimensional printing, freeze-casted porous materials, and electrospinning) according to their uses in tissue engineering, artificial organs, controlled drug delivery and wound healing systems, among others. For this purpose, we map the structure–property–function relationships of nanocellulose-based porous materials and examine the course of actions that are required to translate innovation from the laboratory to industry. Such efforts require attention to regulatory aspects and market pull. Finally, the key challenges and opportunities in this nascent field are critically reviewed.

Publication DOI:
Divisions: College of Engineering & Physical Sciences > Aston Institute of Materials Research (AIMR)
Additional Information: Funding: The authors acknowledge the financial support from the Sao ˜ Paulo Research Foundation [FAPESP; Grants No. 2016/10636-8, 2020/07956- 6, 2018/22214-6, 2022/03247-6], the Brazilian National Council for Scientific and Technological Development [CNPq; ; Grants No 001], the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program [ERC Advanced Grant Agreement No. 788489, “BioElCell”], the Canada Excellence Research Chair Program [CERC-2018-00006], and Canada Foundation for Innovation [Project number 38623]. Copyright © 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY license (
Uncontrolled Keywords: cellulose nanofibrils,cellulose nanocrystals,regenerative medicine,biomaterial,sustainable materials,green nanomaterials
Publication ISSN: 2452-199X
Last Modified: 18 Jul 2024 16:22
Date Deposited: 31 Jul 2023 10:57
Full Text Link: https://linking ... 452199X23002037
Related URLs: https://www.sci ... 452199X23002037 (Publisher URL)
PURE Output Type: Article
Published Date: 2023-11-01
Published Online Date: 2023-07-12
Accepted Date: 2023-06-24
Authors: Ferreira, Filipe v.
Souza, Alana g.
Ajdary, Rubina
De souza, Lucas p. (ORCID Profile 0000-0002-0188-5168)
Lopes, João h.
Correa, Daniel s.
Siqueira, Gilberto
Barud, Hernane s.
Rosa, Derval dos s.
Mattoso, Luiz h.c.
Rojas, Orlando j.



Version: Published Version

License: Creative Commons Attribution

| Preview

Export / Share Citation


Additional statistics for this record