Social Cognitive Disruptions in Multiple Sclerosis: The Role of Executive (Dys)Function

Abstract

Objective: Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system, resulting in a range of potential motor and cognitive impairments. The latter can affect both executive functions that orchestrate general goal-directed behavior and social cognitive processes that support our ability to interact with others and maintain healthy interpersonal relationships. Despite a long history of research into the cognitive symptoms of MS, it remains uncertain if social cognitive disruptions occur independently of, or reflect underlying disturbances to, more foundational executive functions. The present preregistered study investigated this directly. Method: Employing an experimental design, we administered a battery of computerized tasks online to a large sample comprising 134 individuals with MS and 134 age-and sex-matched healthy controls (HCs). Three tasks measured elements of executive function (working memory, response inhibition, and switching) and two assessed components of social cognition disrupted most commonly in MS (emotion perception and theory of mind). Results: Individuals with MS exhibited poorer working memory (d =.31), response inhibition (d = −.26), emotion perception (d =.32), and theory of mind (d =.35) compared with matched HCs. Furthermore, exploratory mediation analyses revealed that working memory performance accounted for approximately 20% of the group differences in both measures of social cognition. Conclusions: Disruptions to working memory appear to serve as one of the mechanisms underpinning disturbances to social cognition in MS. Future research should examine if the benefits of cognitive rehabilitation programs that incorporate working memory training transfer to these social cognitive processes.

Publication DOI: https://doi.org/10.1037/neu0000917
Divisions: College of Health & Life Sciences > School of Psychology
Additional Information: Copyright © 2023 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0; https://creativecommons.org/licenses/by/4.0). This license permits copying and redistributing the work in any medium or format, as well as adapting the material for any purpose, even commercially. Funding: This study was funded by an internal grant from Aston University awarded to Daniel J. Shaw and Charlotte R. Pennington. Open access funding provided by School of Psychology, College of Health and Life Sciences, Aston University.
Uncontrolled Keywords: executive function,multiple sclerosis,social cognition,working memory,Neuropsychology and Physiological Psychology
Publication ISSN: 1931-1559
Last Modified: 28 Feb 2024 18:07
Date Deposited: 06 Jul 2023 17:09
Full Text Link: https://osf.io/2bhmy/
Related URLs: https://osf.io/2bhmy/ (Related URL)
https://psycnet ... -86320-001.html (Publisher URL)
https://osf.io/shukw (Author URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2023-06-29
Published Online Date: 2023-06-29
Accepted Date: 2023-05-15
Authors: Pennington, Charlotte Rebecca (ORCID Profile 0000-0002-5259-642X)
Oxtoby, Michelle Chen-Sien-Yee
Shaw, Daniel Joel (ORCID Profile 0000-0003-1139-8301)

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