Corneal dendritic cells and the subbasal nerve plexus following neurotoxic treatment with oxaliplatin or paclitaxel

Abstract

Immune cell infiltration has been implicated in neurotoxic chemotherapy for cancer treatment. However, our understanding of immune processes is still incomplete and current methods of observing immune cells are time consuming or invasive. Corneal dendritic cells are potent antigen-presenting cells and can be imaged with in-vivo corneal confocal microscopy. Corneal dendritic cell densities and nerve parameters in patients treated with neurotoxic chemotherapy were investigated. Patients treated for cancer with oxaliplatin (n = 39) or paclitaxel (n = 48), 3 to 24 months prior to assessment were recruited along with 40 healthy controls. Immature (ImDC), mature (MDC) and total dendritic cell densities (TotalDC), and corneal nerve parameters were analyzed from in-vivo corneal confocal microscopy images. ImDC was increased in the oxaliplatin group (Median, Md = 22.7 cells/mm 2) compared to healthy controls (Md = 10.1 cells/mm 2, p = 0.001), but not in the paclitaxel group (Md = 10.6 cells/mm 2). ImDC was also associated with higher oxaliplatin cumulative dose (r = 0.33, p = 0.04) and treatment cycles (r = 0.40, p = 0.01). There was no significant difference in MDC between the three groups (p > 0.05). Corneal nerve parameters were reduced in both oxaliplatin and paclitaxel groups compared to healthy controls (p < 0.05). There is evidence of elevation of corneal ImDC in oxaliplatin-treated patients. Further investigation is required to explore this potential link through longitudinal studies and animal or laboratory-based immunohistochemical research.

Publication DOI: https://doi.org/10.1038/s41598-021-02439-0
Divisions: College of Health & Life Sciences > School of Optometry > Optometry
College of Health & Life Sciences > School of Optometry
Additional Information: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Uncontrolled Keywords: Aged,Antineoplastic Agents/adverse effects,Case-Control Studies,Cornea/drug effects,Cross-Sectional Studies,Dendritic Cells/drug effects,Female,Humans,Male,Microscopy, Confocal,Middle Aged,Nerve Fibers/drug effects,Neurotoxicity Syndromes/etiology,Oxaliplatin/adverse effects,Paclitaxel/adverse effects,Time Factors,Treatment Outcome
Publication ISSN: 2045-2322
Last Modified: 11 Apr 2024 07:22
Date Deposited: 21 Jun 2023 08:25
Full Text Link:
Related URLs: https://www.nat ... 598-021-02439-0 (Publisher URL)
PURE Output Type: Article
Published Date: 2021-11-24
Accepted Date: 2021-11-08
Authors: Chiang, Jeremy Chung Bo (ORCID Profile 0000-0002-6133-7411)
Goldstein, David
Tavakoli, Azadeh
Trinh, Terry
Klisser, Jacob
Lewis, Craig R
Friedlander, Michael
Naduvilath, Thomas J
Au, Kimberley
Park, Susanna B
Krishnan, Arun V
Markoulli, Maria

Download

[img]

Version: Published Version

License: Creative Commons Attribution

| Preview

Export / Share Citation


Statistics

Additional statistics for this record