Behavioural and physiological indicators of anxiety reflect shared and distinct profiles across individuals with neurogenetic syndromes

Abstract

Anxiety is heightened in individuals with intellectual disability, particularly in those with specific neurogenetic syndromes. Assessment of anxiety for these individuals is hampered by a lack of appropriate measures that cater for communication impairment, differences in presentation, and overlapping features with co-occurring conditions. Here, we adopt a multi-method approach to identify fine-grained behavioural and physiological (via salivary cortisol) responses to anxiety presses in people with fragile X (FXS; n = 27; M age = 20.11 years; range 6.32 - 47.04 years) and Cornelia de Lange syndromes (CdLS; n = 27; M age = 18.42 years; range 4.28 - 41.08 years), two neurogenetic groups at high risk for anxiety, compared to neurotypical children (NT; n = 21; M age = 5.97 years; range 4.34 - 7.30 years). Results indicate that physical avoidance of feared stimuli and proximity seeking to a familiar adult are prominent behavioural indicators of anxiety/stress in FXS and CdLS. Heightened pervasive physiological arousal was identified in these groups via salivary cortisol. An association between autistic characteristics and anxiety was evident in the FXS group but not in the CdLS group pointing to syndrome-specific nuances in the association between anxiety and autism. This study furthers understanding of the behavioural and physiological presentation of anxiety in individuals with intellectual disability and progresses theoretical developments regarding the development and maintenance of anxiety at the intersection of autism.

Publication DOI: https://doi.org/10.1016/j.psychres.2023.115278
Divisions: College of Health & Life Sciences > School of Psychology
Aston University (General)
Additional Information: Copyright © 2023 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/). Funding: This work was supported by Baily-Thomas Charitable Fund; National Institute for Health Research (NIHR) Applied Research Collaboration (ARC) West Midlands; Cornelia de Lange Syndrome Foundation UK and Ireland; and Cerebra. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care.
Uncontrolled Keywords: Fragile X syndrome,Cornelia de Lange syndrome,Cortisol
Publication ISSN: 0165-1781
Last Modified: 02 Dec 2024 08:55
Date Deposited: 19 Jun 2023 16:30
Full Text Link:
Related URLs: https://www.sci ... 165178123002287 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2023-08
Published Online Date: 2023-05-30
Accepted Date: 2023-05-30
Authors: Crawford, Hayley
Oliver, Chris
Groves, Laura
Bradley, Louise
Smith, Kayla
Hogan, Abigail
Renshaw, Derek
Waite, Jane (ORCID Profile 0000-0002-8676-3070)
Roberts, Jane

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