Long-range phase synchronization of high-frequency oscillations in human cortex

Abstract

Inter-areal synchronization of neuronal oscillations at frequencies below ~100 Hz is a pervasive feature of neuronal activity and is thought to regulate communication in neuronal circuits. In contrast, faster activities and oscillations have been considered to be largely local-circuit-level phenomena without large-scale synchronization between brain regions. We show, using human intracerebral recordings, that 100–400 Hz high-frequency oscillations (HFOs) may be synchronized between widely distributed brain regions. HFO synchronization expresses individual frequency peaks and exhibits reliable connectivity patterns that show stable community structuring. HFO synchronization is also characterized by a laminar profile opposite to that of lower frequencies. Importantly, HFO synchronization is both transiently enhanced and suppressed in separate frequency bands during a response-inhibition task. These findings show that HFO synchronization constitutes a functionally significant form of neuronal spike-timing relationships in brain activity and thus a mesoscopic indication of neuronal communication per se.

Publication DOI: https://doi.org/10.1038/s41467-020-18975-8
Divisions: College of Engineering & Physical Sciences > School of Engineering and Technology > Mechanical, Biomedical & Design
College of Engineering & Physical Sciences > School of Engineering and Technology
Additional Information: © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Funding information: This study was supported by the Academy of Finland (J.M.P., project numbers: 253130, 256472, 281414, 296304, 266745; S.P., 266402, 266745, 303933, 325404), by the Juselius Foundation (J.M.P., S.P.), by the Helsinki University Research Funds (J.M.P., S.P.), and by the Finnish Cultural Foundation (G.A., 12938). The research leading to these results has received funding from the European Union Seventh Framework Program (FP7/2007-2013, J.M.P., S.P.) under grant agreement no. 604102 (Human Brain Project). G.A. was partially funded by Fondazione San Paolo (20670).
Publication ISSN: 2041-1723
Last Modified: 14 Feb 2024 17:45
Date Deposited: 13 Jun 2023 11:32
Full Text Link:
Related URLs: https://www.nat ... 467-020-18975-8 (Publisher URL)
PURE Output Type: Article
Published Date: 2020-10-23
Published Online Date: 2020-10-23
Accepted Date: 2020-09-03
Authors: Arnulfo, Gabriele
Wang, S. H.
Myrov, V.
Toselli, B.
Hirvonen, J.
Fato, M. M.
Nobili, L.
Cardinale, F.
Rubino, A.
Zhigalov, Alexander (ORCID Profile 0000-0002-3359-5093)
Palva, S
Palva, J. Matias

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