A Cross-Sectional Study of Sub-Basal Corneal Nerve Reduction Following Neurotoxic Chemotherapy

Abstract

Purpose: Sub-basal corneal nerves have been shown to change during neuro-toxic chemotherapy treatment. This cross-sectional study investigated corneal nerve morphology in patients who have completed neurotoxic chemotherapy well after treatment cessation and its association with peripheral nerve function. Methods: Central corneal nerve fiber length (CNFL) and inferior whorl length (IWL), average nerve fiber length (ANFL), corneal nerve fiber density (CNFD) and corneal nerve branch density (CNBD), and nerve fiber area (CNFA) were examined using in vivo corneal confocal microscopy in patients with cancer who had completed treatment with either paclitaxel or oxaliplatin between 3 and 24 months prior to assessment in comparison with 2 separate groups of healthy controls. Neurological assessments were conducted including clinician-and patient-reported outcomes, and neurological grading scales. Results: Both paclitaxel-(n = 40) and oxaliplatin-treated (n = 30) groups had reduced IWL and ANFL compared to the respective healthy control groups (n = 15 in each group) (paclitaxel: IWL = P = 0.02, ANFL = P = 0.009; and oxaliplatin: IWL = P = 0.008, ANFL P = 0.02). CNFL and CNFD reduction were observed only in the paclitaxel-treated group compared with healthy controls (P = 0.008 and P = 0.02, respectively), whereas CNFA was reduced in the oxaliplatin-treated group (P = 0.04). IWL reduction correlated with worse fine hand dexterity in chemotherapy-treated patients (r =−0.33, P = 0.007). Conclusions: There is evidence of corneal nerve loss in patients with cancer who have been treated with paclitaxel and oxaliplatin well after treatment cessation associated with worse upper limb function. Translational Relevance: Sub-basal corneal nerve reduction is evident even after cessation of neurotoxic treatment. In vivo corneal confocal microscopy may be useful in the monitoring of nerve function in patients receiving chemotherapy.

Publication DOI: https://doi.org/10.1167/tvst.10.1.24
Divisions: College of Health & Life Sciences > School of Optometry > Optometry
Funding Information: Supported by an Australian Government Research Training Program (RTP) Scholarship awarded by UNSW Sydney to JCB Chiang. This study was supported by a Cancer Institute NSW Program Grant (14/TPG/1-05) and a National Health and Medical Research Council of Au
Additional Information: Copyright © 2021, The Authors. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License [https://creativecommons.org/licenses/by-nc-nd/4.0/] Funding Information: Supported by an Australian Government Research Training Program (RTP) Scholarship awarded by UNSW Sydney to JCB Chiang. This study was supported by a Cancer Institute NSW Program Grant (14/TPG/1-05) and a National Health and Medical Research Council of Australia (NHMRC) Project Grant (1080521). S.B. Park is supported by an NHMRC Career Development Fellowship (1148595).
Uncontrolled Keywords: Chemotherapy-induced peripheral neuropathy,Corneal nerves,In-vivo corneal confocal microscopy,Inferior whorl,Neurotoxic chemotherapy,Biomedical Engineering,Ophthalmology
Publication ISSN: 2164-2591
Last Modified: 16 May 2024 07:24
Date Deposited: 07 Jun 2023 11:41
Full Text Link:
Related URLs: https://tvst.ar ... ticleid=2772188 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2021-01-12
Accepted Date: 2020-12-18
Authors: Chiang, Jeremy Chung Bo (ORCID Profile 0000-0002-6133-7411)
Goldstein, David
Trinh, Terry
Au, Kimberley
Mizrahi, David
Muhlmann, Mark
Crowe, Philip
O’Neill, Siobhan
Edwards, Katie
Park, Susanna B.
Krishnan, Arun V.
Markoulli, Maria

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