Impact of Plasmonic Nanoparticles on Poikilocytosis and Microrheological Properties of Erythrocytes

Abstract

Plasmonic nanoparticles (NP) possess great potential in photothermal therapy and diagnostics. However, novel NP require a detailed examination for potential toxicity and peculiarities of interaction with cells. Red blood cells (RBC) are important for NP distribution and the development of hybrid RBC-NP delivery systems. This research explored RBC alterations induced by noble (Au and Ag) and nitride-based (TiN and ZrN) laser-synthesized plasmonic NP. Optical tweezers and conventional microscopy modalities indicated the effects arising at non-hemolytic levels, such as RBC poikilocytosis, and alterations in RBC microrheological parameters, elasticity and intercellular interactions. Aggregation and deformability significantly decreased for echinocytes independently of NP type, while for intact RBC, all NP except Ag NP increased the interaction forces but had no effect on RBC deformability. RBC poikilocytosis promoted by NP at concentration 50 μg mL−1 was more pronounced for Au and Ag NP, compared to TiN and ZrN NP. Nitride-based NP demonstrated better biocompatibility towards RBC and higher photothermal efficiency than their noble metal counterparts.

Publication DOI: https://doi.org/10.3390/pharmaceutics15041046
Divisions: College of Business and Social Sciences > School of Social Sciences & Humanities > Sociology and Policy
College of Business and Social Sciences > School of Social Sciences & Humanities > Centre for Critical Inquiry into Society and Culture (CCISC)
College of Business and Social Sciences > School of Social Sciences & Humanities
College of Engineering & Physical Sciences > School of Engineering and Technology > Mechanical, Biomedical & Design
College of Engineering & Physical Sciences
College of Engineering & Physical Sciences > Engineering for Health
Additional Information: Copyright © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Funding Information: Current study partially supported by the Suomen Kulttuurirahasto (grant No. 00190188), China Scholarship Council (CSC No. 201706410089) and the INFOTECH and the Academy of Finland (project 325097). The authors also acknowledge the contribution of Russian Science Foundation (Project: 19-72-30012 and Project: 22-65-00096). I.M. acknowledges the support from the Leverhulme Trust and The Royal Society (Ref. no.: APX\R1\211232 APEX Awards 2021). Publisher Copyright: © 2023 by the authors.
Uncontrolled Keywords: aggregation,cell–cell interactions,microrheology,microscopy,optical manipulation,plasmonic nanoparticles,poikilocytosis,red blood cells,Pharmaceutical Science
Publication ISSN: 1999-4923
Last Modified: 06 Jun 2024 07:26
Date Deposited: 03 Apr 2023 11:32
Full Text Link:
Related URLs: https://www.mdp ... -4923/15/4/1046 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2023-04
Published Online Date: 2023-03-23
Accepted Date: 2023-03-17
Authors: Avsievich, Tatiana
Zhu, Ruixue
Popov, Alexey P.
Yatskovskiy, Alexander
Popov, Anton A. (ORCID Profile 0000-0002-1337-8016)
Tikhonowsky, Gleb
Pastukhov, Andrei I.
Klimentov, Sergei
Bykov, Alexander
Kabashin, Andrei
Meglinski, Igor (ORCID Profile 0000-0002-7613-8191)

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