Biswas, Sayantan, Muralidharan, Arumugam R., Betzler, Bjorn Kaijun, Busoy, Joanna Marie, Barathi, Veluchamy A., Tan, Royston K. Y., Low, Wan Yu Shermaine, Milea, Dan, Kathrani, Biten K., Brennan, Noel A. and Najjar, Raymond P (2023). A Duration-Dependent Interaction Between High-Intensity Light and Unrestricted Vision in the Drive for Myopia Control. Investigative Ophthalmology and Visual Science, 64 (3),
Abstract
Purpose: To evaluate the duration-dependent and synergetic impact of high-intensity light (HL) and unrestricted vision (UnV) on lens-induced myopia (LIM) development in chickens. Methods: Myopia was induced in one eye in chicks (10 groups, n = 126) from day 1 posthatching (D1) until day 8 (D8) using –10 diopter (D) lenses. Fellow eyes remained uncovered as controls. Nine groups were exposed daily to 2, 4, or 6 hours of HL (15,000 lux), UnV (removal of –10 D lens), or both (HL + UnV). One group served as the LIM group without any interventions. Ocular axial length (AL), refractive error, and choroidal thickness were measured on D1, D4, and D8. Outcome measures are expressed as interocular difference (IOD = experimental eye – control eye) ± SEM. Results: By D8, LIM increased AL (0.36 ± 0.04 mm), myopic refraction (−9.02 ± 0.37 D), and choroidal thinning (−90.27 ± 16.44 µm) in the LIM group (all, P < 0.001). Compared to the LIM group, exposure to 2, 4, or 6 hours of HL, UnV, or HL + UnV reduced myopic refraction in a duration-dependent manner, with UnV being more effective than HL (P < 0.05). Only 6 hours of HL + UnV (not 2 or 4 hours) prevented LIM and was more effective than UnV (P = 0.004) or HL (P < 0.001) in reducing myopic refraction and more effective than HL (P < 0.001) in reducing axial elongation. Conclusions: Daily exposure to 2, 4, or 6 hours of HL, UnV, or HL + UnV reduced lens-induced myopic refraction in a duration-dependent manner in chickens. Only 6 hours of HL + UnV completely stopped LIM development. The synergetic effect of HL and UnV is dependent on the duration of the interventions.
Publication DOI: | https://doi.org/10.1167/iovs.64.3.31 |
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Divisions: | College of Health & Life Sciences > School of Optometry > Optometry College of Health & Life Sciences Aston University (General) |
Funding Information: | Supported by research grant from the Singapore Government (IAF), Industry Collaboration Project Grant (I1901E0038), and Johnson & Johnson Vision Care to RPN. The funding organization has no role in the design, conduct, and interpretation of the research. |
Additional Information: | Copyright © 2023 The Authors. This work is licensed under a Creative Commons Attribution 4.0 International License. |
Uncontrolled Keywords: | myopia,animal model,unrestricted vision,optical defocus,high-intensity light,axial length,choroid,outdoor time |
Publication ISSN: | 1552-5783 |
Last Modified: | 02 Dec 2024 08:51 |
Date Deposited: | 28 Mar 2023 14:28 |
Full Text Link: | |
Related URLs: |
https://iovs.ar ... ticleid=2785471
(Publisher URL) http://www.scop ... tnerID=8YFLogxK (Scopus URL) |
PURE Output Type: | Article |
Published Date: | 2023-03-23 |
Accepted Date: | 2023-03-08 |
Authors: |
Biswas, Sayantan
(
0000-0001-6011-0365)
Muralidharan, Arumugam R. Betzler, Bjorn Kaijun Busoy, Joanna Marie Barathi, Veluchamy A. Tan, Royston K. Y. Low, Wan Yu Shermaine Milea, Dan Kathrani, Biten K. Brennan, Noel A. Najjar, Raymond P |