Endometallofullerenes and their derivatives:Synthesis, physicochemical properties, and perspective application in biomedicine


We review all aspects of the synthesis, properties, and applications of endometallofullerenes (EMF) over the last 20 years. EMF represent a new class of nanosized objects with specific physicochemical properties defined by the encapsulation of individual atoms and small molecules with significant potential of practical applications in biology and medicine. One such application is an EMF based anticancer drug capable of activating antitumour immune response, inhibition of the tumour development, and inhibition of angiogenesis and metastasis. Another, separate application direction is the use of EMF as contrast agents.

Publication DOI: https://doi.org/10.1016/j.colsurfb.2023.113133
Divisions: College of Engineering & Physical Sciences > School of Informatics and Digital Engineering > Mathematics
College of Engineering & Physical Sciences > Aston Institute of Urban Technology and the Environment (ASTUTE)
College of Engineering & Physical Sciences > Systems analytics research institute (SARI)
College of Engineering & Physical Sciences
Additional Information: Funding Information: This research was funded by the Russian Foundation for Basic Researches , Grant number 18-29-19008 , partially by Kurchatov Institute according to the state assignment for the theme “2.4. Carbon based nanomaterials” and by Governor Fellowship of Leningrad District personally for V.T. Lebedev (2022–2023) . The work was carried out with the financial support of the Ministry of Health of the Russian Federation “Development of molecular design and creation of drugs based on conjugates of carbon nanostructures, targeted delivery vectors and cytotoxic agents for inactivation of tumor stem cells and components of the tumor microenvironment”. Publisher Copyright: Copyright © 2023. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/. The Version of Record can be found here: https://doi.org/10.1016/j.colsurfb.2023.113133
Uncontrolled Keywords: Endometallofullerenes,Functionalization,MRI-diagnostic,Physicochemical properties,Biotechnology,Surfaces and Interfaces,Physical and Theoretical Chemistry,Colloid and Surface Chemistry
Publication ISSN: 1873-4367
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://www.sci ... 0115?via%3Dihub (Publisher URL)
PURE Output Type: Review article
Published Date: 2023-02
Published Online Date: 2023-01-18
Accepted Date: 2023-01-05
Authors: Lebedev, Vasiliy T.
Charykov, Nikolay A.
Shemchuk, Olga S.
Murin, Igor V.
Nerukh, Dmitry A. (ORCID Profile 0000-0001-9005-9919)
Petrov, Andrey V.
Maystrenko, Dmitriy N.
Molchanov, Oleg E.
Sharoyko, Vladimir V.
Semenov, Konstantin N.



Version: Accepted Version

Access Restriction: Restricted to Repository staff only until 18 January 2025.

License: Creative Commons Attribution Non-commercial No Derivatives

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