Direct laser-induced singlet oxygen in biological systems: application from in vitro to in vivo

Abstract

In recent years, there has been increasing interest in the singlet form of oxygen as a regulator of the physiological functions of cells. The use of photosensitisers is a classical mechanism for the excitation of the main triplet form of oxygen and the generation of its singlet form. At the same time, it has been shown that there is a possibility of direct optical excitation of the main oxygen form into the singlet state by light at certain wavelengths. This review article aims to combine recent accumulated experience in the field of direct optical generation of singlet oxygen. We focus on works on the application of a 1267 nm wavelength, which is the most frequently used and well-studied in this area. In this review, we consider the use of laser-induced singlet oxygen in various biomedical applications both at the cellular level and at the level of whole organisms. This review presents the latest results on the use of singlet oxygen for therapeutic effects on cancer cells, as well as for photostimulation of neurons and the vascular and lymphatic systems.

Publication DOI: https://doi.org/10.1109/JSTQE.2023.3246587
Divisions: College of Engineering & Physical Sciences > Aston Institute of Photonics Technology (AIPT)
College of Engineering & Physical Sciences
Additional Information: This work is licensed under a Creative Commons Attribution 4.0 License. For more information, see https://creativecommons.org/licenses/by/4.0
Uncontrolled Keywords: singlet oxygen,direct optical generation,cancer,cardiovascular system,ATP production,photostimulation
Publication ISSN: 1077-260X
Last Modified: 20 Jun 2024 07:23
Date Deposited: 24 Feb 2023 08:39
Full Text Link: https://ieeexpl ... ument/10049092/
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Review article
Published Date: 2023-07-01
Published Online Date: 2023-02-20
Accepted Date: 2023-02-11
Authors: Dremin, Viktor (ORCID Profile 0000-0001-6974-3505)
Semyachkina-Glushkovskaya, Oxana
Rafailov, Edik (ORCID Profile 0000-0002-4152-0120)

Download

[img]

Version: Accepted Version

License: Creative Commons Attribution

| Preview

Export / Share Citation


Statistics

Additional statistics for this record