Intranasal Delivery of Liposomes to Glioblastoma by Photostimulation of the Lymphatic System


The blood–brain barrier (BBB) limits the delivery of majority of cancer drugs and thereby complicates brain tumor treatment. The nasal-brain-lymphatic system is discussed as a pathway for brain drug delivery overcoming the BBB. However, in most cases, this method is not sufficient to achieve a therapeutic effect due to brain drug delivery in a short distance. Therefore, it is necessary to develop technologies to overcome the obstacles facing nose-to-brain delivery of promising pharmaceuticals. In this study, we clearly demonstrate intranasal delivery of liposomes to the mouse brain reaching glioblastoma (GBM). In the experiments with ablation of the meningeal lymphatic network, we report an important role of meningeal pathway for intranasal delivery of liposomes to the brain. Our data revealed that GBM is characterized by a dramatic reduction of intranasal delivery of liposomes to the brain that was significantly improved by near-infrared (1267 nm) photostimulation of the lymphatic vessels in the area of the cribriform plate and the meninges. These results open new perspectives for non-invasive improvement of efficiency of intranasal delivery of cancer drugs to the brain tissues using nanocarriers and near-infrared laser-based therapeutic devices, which are commercially available and widely used in clinical practice.

Publication DOI:
Divisions: College of Engineering & Physical Sciences > Aston Institute of Photonics Technology (AIPT)
College of Engineering & Physical Sciences
Additional Information: Copyright © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Uncontrolled Keywords: Article,liposomes,nasal-brain lymphatic system,intranasal drug delivery,photostimulation,glioblastoma
Publication ISSN: 1999-4923
Last Modified: 20 Jun 2024 07:21
Date Deposited: 26 Jan 2023 09:09
Full Text Link:
Related URLs: https://www.mdp ... 99-4923/15/1/36 (Publisher URL)
PURE Output Type: Article
Published Date: 2022-12-22
Published Online Date: 2022-12-22
Accepted Date: 2022-12-19
Submitted Date: 2022-11-07
Authors: Semyachkina-Glushkovskaya, Oxana
Shirokov, Alexander
Blokhina, Inna
Telnova, Valeria
Vodovozova, Elena
Alekseeva, Anna
Boldyrev, Ivan
Fedosov, Ivan
Dubrovsky, Alexander
Khorovodov, Alexandr
Terskov, Andrey
Evsukova, Arina
Elovenko, Daria
Adushkina, Viktoria
Tzoy, Maria
Agranovich, Ilana
Kurths, Jürgen
Rafailov, Edik (ORCID Profile 0000-0002-4152-0120)



Version: Published Version

License: Creative Commons Attribution

| Preview

Export / Share Citation


Additional statistics for this record