Semyachkina-Glushkovskaya, Oxana, Shirokov, Alexander, Blokhina, Inna, Telnova, Valeria, Vodovozova, Elena, Alekseeva, Anna, Boldyrev, Ivan, Fedosov, Ivan, Dubrovsky, Alexander, Khorovodov, Alexandr, Terskov, Andrey, Evsukova, Arina, Elovenko, Daria, Adushkina, Viktoria, Tzoy, Maria, Agranovich, Ilana, Kurths, Jürgen and Rafailov, Edik (2022). Intranasal Delivery of Liposomes to Glioblastoma by Photostimulation of the Lymphatic System. Pharmaceutics, 15 (1),
Abstract
The blood–brain barrier (BBB) limits the delivery of majority of cancer drugs and thereby complicates brain tumor treatment. The nasal-brain-lymphatic system is discussed as a pathway for brain drug delivery overcoming the BBB. However, in most cases, this method is not sufficient to achieve a therapeutic effect due to brain drug delivery in a short distance. Therefore, it is necessary to develop technologies to overcome the obstacles facing nose-to-brain delivery of promising pharmaceuticals. In this study, we clearly demonstrate intranasal delivery of liposomes to the mouse brain reaching glioblastoma (GBM). In the experiments with ablation of the meningeal lymphatic network, we report an important role of meningeal pathway for intranasal delivery of liposomes to the brain. Our data revealed that GBM is characterized by a dramatic reduction of intranasal delivery of liposomes to the brain that was significantly improved by near-infrared (1267 nm) photostimulation of the lymphatic vessels in the area of the cribriform plate and the meninges. These results open new perspectives for non-invasive improvement of efficiency of intranasal delivery of cancer drugs to the brain tissues using nanocarriers and near-infrared laser-based therapeutic devices, which are commercially available and widely used in clinical practice.
Publication DOI: | https://doi.org/10.3390/pharmaceutics15010036 |
---|---|
Divisions: | College of Engineering & Physical Sciences > Aston Institute of Photonics Technology (AIPT) College of Engineering & Physical Sciences |
Additional Information: | Copyright © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
Uncontrolled Keywords: | Article,liposomes,nasal-brain lymphatic system,intranasal drug delivery,photostimulation,glioblastoma |
Publication ISSN: | 1999-4923 |
Last Modified: | 14 Oct 2024 07:49 |
Date Deposited: | 26 Jan 2023 09:09 |
Full Text Link: | |
Related URLs: |
https://www.mdp ... 99-4923/15/1/36
(Publisher URL) |
PURE Output Type: | Article |
Published Date: | 2022-12-22 |
Published Online Date: | 2022-12-22 |
Accepted Date: | 2022-12-19 |
Submitted Date: | 2022-11-07 |
Authors: |
Semyachkina-Glushkovskaya, Oxana
Shirokov, Alexander Blokhina, Inna Telnova, Valeria Vodovozova, Elena Alekseeva, Anna Boldyrev, Ivan Fedosov, Ivan Dubrovsky, Alexander Khorovodov, Alexandr Terskov, Andrey Evsukova, Arina Elovenko, Daria Adushkina, Viktoria Tzoy, Maria Agranovich, Ilana Kurths, Jürgen Rafailov, Edik ( 0000-0002-4152-0120) |