Manuka honey in combination with azithromycin shows potential for improved activity against Mycobacterium abscessus


Mycobacterium abscessus is an increasingly prevalent opportunistic pathogen causing both pulmonary and skin and soft tissue infections. It is of increasing concern for immunocompromised individuals, such as those with cystic fibrosis, due to its highly drug resistant nature and ability to evade the host immune system. Current treatments for M. abscessus pulmonary infections are largely ineffective and treatment outcomes are generally poor, thus we urgently require new treatments to combat these infections. Recently, it has been demonstrated that manuka honey is effective against M. abscessus and can improve the inhibitory effect of amikacin. Here, we explore the potential improvement of both azithromycin and tobramycin with the addition of manuka honey against M. abscessus complex. Improved growth inhibition was observed for azithromycin with manuka honey against all M. abscessus subspecies. Improved bactericidal activity was also observed. Importantly, the macrolide resistant M. abscessus subsp. bolletii showed improved inhibition and bactericidal activity was obtained in response to 0.117 g/mL manuka honey MGO40 with 16 µg/mL azithromycin. No improved activity was observed for tobramycin and manuka honey against any of the M. abscessus isolates tested. This demonstrates the potential for antibiotic enhancement by the addition of manuka honey, furthering the applications of therapeutic manuka honey.

Publication DOI:
Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences
Additional Information: Copyright © 2022, The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license ( Funding & Acknowlegements: J.A.G.C. is grateful to the Academy of Medical Sciences, Global Challenges Research Fund, Birmingham Women’s and Children’s Hospital Charity Research Foundation and Give A Child Health Fund for their continued support of the Mycobacterial Research Group at Aston University. This research was funded by the Academy of Medical Sciences/the British Heart Foundation/the Government Department of Business, Energy and Industrial Strategy/Global Challenges Research Fund/the Wellcome Trust Springboard Award [SBF003\1088]. VCN is supported with a PhD Studentship jointly funded by Give A Child Health Fund and Aston University. JH is supported by a Venture Innovation Award from the Cystic Fibrosis Trust, UK, VIA Award Number: 098.
Uncontrolled Keywords: Azithromycin,Synergy,Manuka honey,Antimicrobial,Mycobacterium abscessus,Applied Microbiology and Biotechnology,Molecular Biology,Cell Biology,Microbiology
Publication ISSN: 2468-2330
Last Modified: 06 Jun 2024 07:20
Date Deposited: 15 Dec 2022 11:13
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Related URLs: https://www.sci ... 0196?via%3Dihub (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2022-12
Published Online Date: 2022-11-17
Accepted Date: 2022-11-16
Submitted Date: 2022-10-17
Authors: Nolan, Victoria C
Harrison, James
Cox, Jonathan A G (ORCID Profile 0000-0001-5208-4056)



Version: Published Version

License: Creative Commons Attribution

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