The role of ADAM10 in astrocytes: Implications for Alzheimer’s disease

Abstract

Much of the early research into AD relies on a neuron-centric view of the brain, however, evidence of multiple altered cellular interactions between glial cells and the vasculature early in AD has been demonstrated. As such, alterations in astrocyte function are widely recognized a contributing factor in the pathogenesis of AD. The processes by which astrocytes may be involved in AD make them an interesting target for therapeutic intervention, but in order for this to be most effective, there is a need for the specific mechanisms involving astrocyte dysfunction to be investigated. “α disintegrin and metalloproteinase” 10 (ADAM10) is capable of proteolytic cleavage of the amyloid precursor protein which prevents amyloid-β generation. As such ADAM10 has been identified as an interesting enzyme in AD pathology. ADAM10 is also known to play a role in a significant number of cellular processes, most notable in notch signaling and in inflammatory processes. There is a growing research base for the involvement of ADAM10 in regulating astrocytic function, primarily from an immune perspective. This review aims to bring together available evidence for ADAM10 activity in astrocytes, and how this relates to AD pathology.

Publication DOI: https://doi.org/10.3389/fnagi.2022.1056507
Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences
College of Health & Life Sciences > Chronic and Communicable Conditions
College of Health & Life Sciences > Clinical and Systems Neuroscience
Additional Information: © 2022 Elsworthy, Hill, Dunleavy and Aldred. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Uncontrolled Keywords: Aging Neuroscience,astrocyte,ADAM10 (a disintegrin and metalloprotease 10),inflammation,Alzheimer’s disease,amyloid-beta
Publication ISSN: 1663-4365
Last Modified: 13 Jun 2024 07:25
Date Deposited: 15 Dec 2022 09:47
Full Text Link:
Related URLs: https://www.fro ... 22.1056507/full (Publisher URL)
PURE Output Type: Review article
Published Date: 2022-11-30
Published Online Date: 2022-11-30
Accepted Date: 2022-11-14
Submitted Date: 2022-09-28
Authors: Elsworthy, Richard J.
Hill, Eric J. (ORCID Profile 0000-0002-9419-1500)
Dunleavy, Connor
Aldred, Sarah

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