Gardner, Michael P., Wang, Jingya, Hazlehurst, Jonathan M., Sainsbury, Chris, Blissett, Jacqueline, Nirantharakumar, Krishnarajah, Thomas, Neil and Bellary, Srikanth (2022). Risk of progression from pre-diabetes to type 2 diabetes in a large UK adult cohort. Diabetic medicine ,
Abstract
AIMS: People with pre-diabetes are at high risk of progressing to type 2 diabetes. This progression is not well characterised by ethnicity, deprivation and age, which we describe in a large cohort of individuals with pre-diabetes. METHODS: A retrospective cohort study with The Health Improvement Network (THIN) database was conducted. Patients aged 18 years and over and diagnosed with pre-diabetes [HbA1c 42 mmol/mol (6.0%) to 48 mmol/mol (6.5%) were included]. Cox proportional hazards regression was used to calculate adjusted hazard rate ratios (aHR) for the risk of progression from pre-diabetes to type 2 diabetes for each of the exposure categories [ethnicity, deprivation (Townsend), age and body mass index (BMI)] separately. RESULTS: Of the baseline population with pre-diabetes (n = 397,853), South Asian (aHR 1.31; 95% CI 1.26-1.37) or Mixed-Race individuals (aHR 1.22; 95% CI 1.11-1.33) had an increased risk of progression to type 2 diabetes compared with those of white European ethnicity. Likewise, deprivation (aHR 1.17; 95% CI 1.14-1.20; most vs. least deprived) was associated with an increased risk of progression. Both younger (aHR 0.63; 95% CI 0.58-0.69; 18 to <30 years) and older individuals (aHR 0.85; 95% CI 0.84-0.87; ≥65 years) had a slower risk of progression from pre-diabetes to type 2 diabetes, than middle-aged (40 to <65 years) individuals. CONCLUSIONS: South Asian or Mixed-Race individuals and people with social deprivation had an increased risk of progression from pre-diabetes to type 2 diabetes. Clinicians need to recognise the differing risk across their patient populations to implement appropriate prevention strategies.
Publication DOI: | https://doi.org/10.1111/dme.14996 |
---|---|
Divisions: | College of Health & Life Sciences > School of Psychology College of Health & Life Sciences > Aston Institute of Health & Neurodevelopment (AIHN) College of Health & Life Sciences College of Health & Life Sciences > School of Biosciences College of Health & Life Sciences > Chronic and Communicable Conditions Aston University (General) |
Additional Information: | Copyright © 2022, The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License [https://creativecommons.org/licenses/by-nc/4.0/], which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. Funding statement: This study was funded by both the Type 2 Diabetes in the Youth (T2DMY) project and West Midlands NIHR Clinical Research Network (CRN). |
Uncontrolled Keywords: | epidemiology,incidence,pre-diabetes,progression,type 2 diabetes,Internal Medicine,Endocrinology, Diabetes and Metabolism,Endocrinology |
Publication ISSN: | 1464-5491 |
Last Modified: | 02 Dec 2024 08:45 |
Date Deposited: | 14 Nov 2022 16:57 |
Full Text Link: | |
Related URLs: |
https://onlinel ... .1111/dme.14996
(Publisher URL) http://www.scop ... tnerID=8YFLogxK (Scopus URL) |
PURE Output Type: | Article |
Published Date: | 2022-10-29 |
Published Online Date: | 2022-10-29 |
Accepted Date: | 2022-10-25 |
Authors: |
Gardner, Michael P.
Wang, Jingya Hazlehurst, Jonathan M. Sainsbury, Chris Blissett, Jacqueline ( 0000-0002-0275-6413) Nirantharakumar, Krishnarajah Thomas, Neil Bellary, Srikanth ( 0000-0002-5924-5278) |