Sources of 7-ketocholesterol, metabolism and inactivation strategies: food and biomedical applications

Abstract

Graphical abstract Abstract 7-Ketocholesterol (or 7-oxocholesterol) is an oxysterol essentially formed by cholesterol autoxidation. It is often found at enhanced levels in the body fluids and/or target tissues of patients with age-related diseases (cardiovascular, neuronal, and ocular diseases) as well as in subjects concerned with civilization diseases (type 2 diabetes, bowel diseases, and metabolic syndrome). The involvement of increased 7-ketocholesterol levels in the pathophysiology of these diseases is widely suspected. Indeed, 7-ketocholesterol at elevated concentrations is a powerful inducer of oxidative stress, inflammation, and cellular degeneration which are common features of all these diseases. It is important to better know the origin of 7-ketocholesterol (diet, incidence of environmental factors, and endogenous formation (autoxidation and enzymatic synthesis)) and its inactivation mechanisms which include esterification, sulfation, oxidation, and reduction. This knowledge will make it possible to act at different levels to regulate 7-ketocholesterol level and counteract its toxicity in order to limit the incidence of diseases associated with this oxysterol. These different points as well as food and biomedical applications are addressed in this review.

Publication DOI: https://doi.org/10.1530/rem-22-0005
Divisions: College of Health & Life Sciences > Aston Medical School
College of Health & Life Sciences > Aston Medical School > Translational Medicine Research Group (TMRG)
Additional Information: © The authors 2022. CC BY 4.0
Last Modified: 24 May 2024 07:17
Date Deposited: 29 Jul 2022 08:20
Full Text Link:
Related URLs: https://rem.bio ... ?body=pdf-40788 (Publisher URL)
PURE Output Type: Review article
Published Date: 2022-07-14
Accepted Date: 2022-05-31
Authors: Ghzaiel, Imen
Sassi, Khouloud
Zarrouk, Amira
Ghosh, Shubhrima
Dias, Irundika H K (ORCID Profile 0000-0002-6620-8221)
Nury, Thomas
Ksila, Mohamed
Essadek, Soukaina
Tahri Joutey, Mounia
Brahmi, Fatiha
Mihoubi, Wafa
Rup-Jacques, Sandrine
Samadi, Mohammad
Rezig, Leila
Meziane, Smail
Ghrairi, Taoufik
Masmoudi-Kouki, Olfa
Hammami, Sonia
Nasser, Boubker
Hammami, Mohamed
Wang, Yuqin
Griffiths, William J
Vejux, Anne
Lizard, Gérard

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