Simulation of thermal field distribution in biological tissue and cell culture media irradiated with infrared wavelengths

Abstract

In recent years, there has been a growing interest in the singlet form of oxygen as a regulator of the physiological functions of cells. One of the ways to generate singlet oxygen is direct optical excitation of the triplet oxygen form. Since molecular oxygen weakly absorbs light, high power is required to obtain sufficient concentrations of singlet oxygen. However, the increase in the radiation power of laser can induce a local temperature increase around the laser spot. This may be critical considering the temperature governs every biological reaction within living cells, in particular. Here, the interaction of laser radiation of infrared wavelengths, generating singlet oxygen, with biological tissues and cell culture media was simulated. Using the COMSOL Multiphysics software, the thermal field distribution in the volume of skin, brain tissue and cell culture media was obtained depending on the wavelength, power and exposure time. The results demonstrate the importance of taking temperature into account when conducting experimental studies at the cellular and organismal levels.

Publication DOI: https://doi.org/10.1364/OE.454012
Divisions: College of Engineering & Physical Sciences > Aston Institute of Photonics Technology (AIPT)
College of Engineering & Physical Sciences
Funding Information: Funding. H2020 Marie Skłodowska-Curie Actions (839888); H2020 Future and Emerging Technologies (863214); Russian Federation Government (075-15-2019-1877); Council on grants of the President of the Russian Federation (MK-398.2021.4); Russian Science Founda
Additional Information: Funding Information: Funding. H2020 Marie Skłodowska-Curie Actions (839888); H2020 Future and Emerging Technologies (863214); Russian Federation Government (075-15-2019-1877); Council on grants of the President of the Russian Federation (MK-398.2021.4); Russian Science Foundation (21-75-00086). Publisher Copyright: © 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement
Uncontrolled Keywords: Atomic and Molecular Physics, and Optics
Publication ISSN: 1094-4087
Last Modified: 18 Jun 2024 07:42
Date Deposited: 29 Jun 2022 10:37
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://opg.opt ... 23078&id=476846 (Publisher URL)
PURE Output Type: Article
Published Date: 2022-06-20
Published Online Date: 2022-06-09
Accepted Date: 2022-04-29
Authors: Dremin, Viktor (ORCID Profile 0000-0001-6974-3505)
Novikova, Irina
Rafailov, Edik (ORCID Profile 0000-0002-4152-0120)

Download

[img]

Version: Published Version

License: ["licenses_description_other" not defined]

| Preview

Export / Share Citation


Statistics

Additional statistics for this record