Cardiovascular Biomarkers: Lessons of the Past and Prospects for the Future


Cardiovascular diseases (CVDs) are a major healthcare burden on the population worldwide. Early detection of this disease is important in prevention and treatment to minimise morbidity and mortality. Biomarkers are a critical tool to either diagnose, screen, or provide prognostic information for pathological conditions. This review discusses the historical cardiac biomarkers used to detect these conditions, discussing their application and their limitations. Identification of new biomarkers have since replaced these and are now in use in routine clinical practice, but still do not detect all disease. Future cardiac biomarkers are showing promise in early studies, but further studies are required to show their value in improving detection of CVD above the current biomarkers. Additionally, the analytical platforms that would allow them to be adopted in healthcare are yet to be established. There is also the need to identify whether these biomarkers can be used for diagnostic, prognostic, or screening purposes, which will impact their implementation in routine clinical practice.

Publication DOI:
Divisions: College of Health & Life Sciences > Aston Medical School
Additional Information: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// 4.0/)
Uncontrolled Keywords: Biomarkers,Cardiovascular diseases,Future biomarkers,Catalysis,Molecular Biology,Spectroscopy,Computer Science Applications,Physical and Theoretical Chemistry,Organic Chemistry,Inorganic Chemistry
Publication ISSN: 1422-0067
Last Modified: 17 Apr 2024 07:22
Date Deposited: 13 Jun 2022 14:08
Full Text Link:
Related URLs: https://www.mdp ... 0067/23/10/5680 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Review article
Published Date: 2022-05-19
Accepted Date: 2022-05-11
Submitted Date: 2022-04-30
Authors: Omran, Farah
Kyrou, Ioannis (ORCID Profile 0000-0002-6997-3439)
Osman, Faizel
Lim, Ven Gee
Randeva, Harpal Singh
Chatha, Kamaljit



Version: Published Version

License: Creative Commons Attribution

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