Armstrong, Richard A. (2008). Spatial correlations between beta-amyloid (A beta) deposits and blood vessels in familial Alzheimer's disease. Folia Neuropathologica, 46 (4), pp. 241-248.
Abstract
In sporadic Alzheimer’s disease (SAD), the classic (‘dense-cored’) ß-amyloid (Aß) deposits are aggregated around the larger blood vessels in the upper laminae of the cerebral cortex. To determine whether a similar relationship exists in familial AD (FAD), the spatial correlations between the diffuse, primitive, and classic ß-amyloid (Aß deposits and blood vessels were studied in ten FAD cases including cases linked to amyloid precursor protein (APP) and presenilin (PSEN) gene mutations and expressing apolipoprotein E (apo E) allele E4. Sections of frontal cortex were immunolabelled with antibodies against Aß and with collagen IV to reveal the Aß deposits and blood vessel profiles. In the FAD cases as a whole, Aßdeposits were distributed in clusters. There was a positive spatial correlation between the clusters of the diffuse Aßdeposits and the larger (>10 µm) and smaller diameter (<10 µm) blood vessels in one and three cases respectively. The primitive Aß deposits were spatially correlated with larger and smaller blood vessels each in four cases and the classic deposits in three and four cases respectively. Apo E genotype of the patient did not influence spatial correlation with blood vessels. Hence, spatial correlations between the classic deposits and larger diameter blood vessels were significantly less frequent in FAD compared with SAD. It was concluded that both Aß deposit morphology and AD subtype determine spatial correlations with blood vessels in AD.
Divisions: | College of Health & Life Sciences > School of Optometry > Optometry College of Health & Life Sciences > School of Optometry > Optometry & Vision Science Research Group (OVSRG) College of Health & Life Sciences College of Health & Life Sciences > School of Optometry > Vision, Hearing and Language College of Health & Life Sciences > Clinical and Systems Neuroscience |
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Additional Information: | Creative Commons Attribution Non-Commercial Share Alike International 4.0 |
Uncontrolled Keywords: | clustering,frontal cortex,blood vessels,diffusion,perivascular clearance,spatial correlation |
Publication ISSN: | 1509-572X |
Last Modified: | 30 Sep 2024 09:47 |
Date Deposited: | 27 Apr 2010 11:47 |
Full Text Link: | |
Related URLs: |
https://www.ter ... ,11572,1,1.html
(Publisher URL) |
PURE Output Type: | Article |
Published Date: | 2008 |
Authors: |
Armstrong, Richard A.
(
0000-0002-5046-3199)
|