Prevalence of anxiety symptomatology and diagnosis in syndromic intellectual disability: a systematic review and meta-analysis


Individuals with syndromic intellectual disability are at increased risk of experiencing anxiety. Comparing prevalence estimates of anxiety will allow the identification of at-risk groups and inform causal pathways of anxiety. No known study has explored estimates of anxiety symptomatology and diagnosis, including specific anxiety profiles, across groups whilst accounting for methodological quality of studies. This systematic review and meta-analysis aimed to fill this gap. Prior to review completion, methodology and analysis plans were registered and documented in a protocol (CRD42019123561). Data from 83 papers, involving a pooled sample of 13,708 across eight syndromes were synthesised using a random effects model. Anxiety prevalence ranged from 9% (95% CI: 4-14) in Down syndrome to 73% in Rett syndrome (95% CI: 70-77). Anxiety prevalence across syndromic intellectual disability was higher than for intellectual disability of mixed aetiology and general population estimates. Substantial variability between syndromes identified groups at higher risk than others. The identification of high-risk groups is crucial for early intervention, allowing us to refine models of risk and identify divergent profiles.

Publication DOI:
Divisions: College of Health & Life Sciences > School of Psychology
College of Health & Life Sciences
College of Health & Life Sciences > Aston Institute of Health & Neurodevelopment (AIHN)
Additional Information: CC BY 4.0 Funding: This work was supported by The Baily Thomas Charitable Fund, grant number (5009-7975).
Uncontrolled Keywords: Anxiety,Intellectual disability,Meta-analysis,Prevalence,Review,Syndromes,Neuropsychology and Physiological Psychology,Cognitive Neuroscience,Behavioral Neuroscience
Publication ISSN: 1873-7528
Last Modified: 22 May 2024 07:20
Date Deposited: 06 Jun 2022 08:20
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Related URLs: https://www.sci ... 2081?via%3Dihub (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Review article
Published Date: 2022-07
Published Online Date: 2022-06-02
Accepted Date: 2022-05-30
Authors: Edwards, Georgina
Jones, Chris
Pearson, Effie (ORCID Profile 0000-0002-4328-1653)
Royston, Rachel
Oliver, Christopher
Tarver, Joanne (ORCID Profile 0000-0003-0555-6043)
Crawford, Hayley
Shelley, Lauren
Waite, Jane (ORCID Profile 0000-0002-8676-3070)



Version: Accepted Version

License: Creative Commons Attribution

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