Dapsone is an anticatalysis for Alzheimer's disease exacerbation

Abstract

Brain inflammation generally accelerates neurodegeneration. Alzheimer's disease (AD) triggers an innate immune response by activating a cytosolic DNA sensor cyclic-GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) signaling pathway. Our study investigated patients with leprosy and AD. They were treated with dapsone (4,4′-diaminodiphenyl sulfone, DDS) as a neuroinflammasome competitor and cGAS/STING pathway inhibitor. Four groups were defined: Treatment (T) 1: DDS prescribed AD diagnosed, T 2: DDS prescribed AD undiagnosed, T 3 DDS unprescribed AD diagnosed, and T 4: DDS unprescribed AD undiagnosed. Dapsone effects on AD can be clearly distinguished according to dapsone presence or absence. T1:T3 proved that the incidence of AD was significantly reduced by dapsone. T2:T3 proved that the prevalence of AD was significantly high without dapsone. T1:T4 proved that the prevalence decreased when taking dapsone. Our study demonstrates that dapsone can prevent AD exacerbation and may represent a preventive therapeutic option for exacerbated AD.

Publication DOI: https://doi.org/10.1016/j.isci.2022.104274
Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences > Chronic and Communicable Conditions
College of Health & Life Sciences
College of Health & Life Sciences > School of Biosciences > Cellular and Molecular Biomedicine
Funding Information: We thank Sorokdo National Hospital and the Ministry of Health and Welfare for collecting research data. In addition, we thank Sister Marianne Stoeger, who worked at a hospital in Innsbruck, who joined Sorok Island in February 1962 and Sister Margaritha Pi
Additional Information: © 2022 The Authors. This is an open access article under the CC BY-NC-ND license 4.0
Uncontrolled Keywords: Biological sciences,Clinical neuroscience,Health sciences,Neuroscience,General
Publication ISSN: 2589-0042
Last Modified: 20 May 2024 07:40
Date Deposited: 23 May 2022 11:17
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://www.sci ... 589004222005442 (Publisher URL)
PURE Output Type: Article
Published Date: 2022-05-20
Published Online Date: 2022-04-20
Accepted Date: 2022-04-11
Authors: Lee, Jong Hoon
Kanwar, Badar
Lee, Chul Joong
Sergi, Consolato
Coleman, Michael D. (ORCID Profile 0000-0002-5510-6852)

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