Lee, Jong Hoon, Kanwar, Badar, Lee, Chul Joong, Sergi, Consolato and Coleman, Michael D. (2022). Dapsone is an anticatalysis for Alzheimer's disease exacerbation. iScience, 25 (5),
Abstract
Brain inflammation generally accelerates neurodegeneration. Alzheimer's disease (AD) triggers an innate immune response by activating a cytosolic DNA sensor cyclic-GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) signaling pathway. Our study investigated patients with leprosy and AD. They were treated with dapsone (4,4′-diaminodiphenyl sulfone, DDS) as a neuroinflammasome competitor and cGAS/STING pathway inhibitor. Four groups were defined: Treatment (T) 1: DDS prescribed AD diagnosed, T 2: DDS prescribed AD undiagnosed, T 3 DDS unprescribed AD diagnosed, and T 4: DDS unprescribed AD undiagnosed. Dapsone effects on AD can be clearly distinguished according to dapsone presence or absence. T1:T3 proved that the incidence of AD was significantly reduced by dapsone. T2:T3 proved that the prevalence of AD was significantly high without dapsone. T1:T4 proved that the prevalence decreased when taking dapsone. Our study demonstrates that dapsone can prevent AD exacerbation and may represent a preventive therapeutic option for exacerbated AD.
| Publication DOI: | https://doi.org/10.1016/j.isci.2022.104274 |
|---|---|
| Divisions: | College of Health & Life Sciences > Aston Pharmacy School College of Health & Life Sciences > Chronic and Communicable Conditions College of Health & Life Sciences College of Health & Life Sciences > School of Biosciences > Cellular and Molecular Biomedicine |
| Funding Information: | We thank Sorokdo National Hospital and the Ministry of Health and Welfare for collecting research data. In addition, we thank Sister Marianne Stoeger, who worked at a hospital in Innsbruck, who joined Sorok Island in February 1962 and Sister Margaritha Pissarek entered Sorok Island in October 1967. They treated the control group of this study for 40 years with dedication, free of charge, and we decided to call this AD study 'Marianne and Margaritha treatment'. JL's older sister, Young Soo Lee, a genius painter and designer, who has shown improvement in cognitive function in dementia for 10 years even after undergoing cerebral hemorrhage, CPR, and two surgeries, who have been the constant motivation for this study and the thesis. Six hours before we heard from the editorial office, we heard that she had passed away. She repainted her pictures and read books. Conceptualization, J.L.; Methodology, J.L.; Investigation, B.K. C.J.L, and J.L.; Resources, C.J.L. and J.L.; Data Curation, J.L.; Writing ? Original Draft, J.L.; Writing ? Review & Editing, C.S. and M.D.C.; Visualization, J.L.; Supervision, B.K. C.J.L, C.S. and M.D.C.; Project Administration, J.L. The authors declare no competing interests. |
| Additional Information: | © 2022 The Authors. This is an open access article under the CC BY-NC-ND license 4.0 |
| Uncontrolled Keywords: | Biological sciences,Clinical neuroscience,Health sciences,Neuroscience,General |
| Publication ISSN: | 2589-0042 |
| Last Modified: | 20 Feb 2026 11:28 |
| Date Deposited: | 23 May 2022 11:17 |
| Full Text Link: | |
| Related URLs: |
https://www.sco ... ons/85129475992
(Scopus URL) https://www.sci ... 589004222005442 (Publisher URL) |
PURE Output Type: | Article |
| Published Date: | 2022-05-20 |
| Published Online Date: | 2022-04-20 |
| Accepted Date: | 2022-04-11 |
| Authors: |
Lee, Jong Hoon
Kanwar, Badar Lee, Chul Joong Sergi, Consolato Coleman, Michael D. ( 
0000-0002-5510-6852)
|
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