High dietary nucleotide consumption for one week increases circulating uric acid concentrations but does not compromise metabolic health: a randomised controlled trial


Background & Aims Elevated circulating uric acid concentrations have been linked to various cardio-metabolic diseases. Bolus consumption of a nucleotide-rich dietary protein source increases postprandial serum uric acid concentrations. We assessed the impact of twice-daily nucleotide-rich mixed-meal consumption for one week on postabsorptive serum uric acid concentrations, insulin sensitivity (IS), glycaemic control and the plasma lipidome. Methods Twenty healthy adults participated in a randomised, controlled, parallel-group trial in which they consumed a 7 d fully-controlled eucaloric diet where lunch and dinner contained either nucleotide-depleted (LOW) or high-nucleotide (HIGH) mycoprotein. Postabsorptive blood samples were obtained pre, throughout and post-intervention, and oral glucose tolerance tests were performed pre- and post-intervention. Daily waking urine samples and 24h continuous blood glucose measurements were collected throughout. Results Postabsorptive serum uric acid concentrations remained unchanged in LOW but increased throughout the intervention week in HIGH (from 295±17 to 472±29 μmol.L-1 by day 6; P

Publication DOI: https://doi.org/10.1016/j.clnesp.2022.04.022
Divisions: College of Engineering & Physical Sciences
College of Engineering & Physical Sciences > School of Infrastructure and Sustainable Engineering > Chemical Engineering & Applied Chemistry
Additional Information: © 2022, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords: Metabolic health,Mycoprotein,Nucleic acids,Nucleotides,Serum uric acid,Endocrinology, Diabetes and Metabolism,Nutrition and Dietetics
Publication ISSN: 2405-4577
Last Modified: 10 Jun 2024 07:42
Date Deposited: 28 Apr 2022 12:34
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Related URLs: https://www.sci ... 2479?via%3Dihub (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2022-06
Published Online Date: 2022-04-25
Accepted Date: 2022-04-20
Authors: Coelho, Mariana OC.
Monteyne, Alistair J.
Kamalanathan, Ishara D.
Najdanovic-Visak, Vesna (ORCID Profile 0000-0002-1035-0982)
Finnigan, Tim JA.
Stephens, Francis B.
Wall, Benjamin T.

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