A cytostatic drug from the class of triazine derivatives:Its properties in aqueous solutions, cytotoxicity, and therapeutic activity


We present a comprehensive study of a water-soluble substance from the class of triazine derivatives alkylating agents. The performed physicochemical investigations of this cytostatic drug's aqueous solutions include the measurements of density, viscosity, speed of sound, refraction index, stability, solubility, distribution between water and octan-1-ol, as well as electronic structure calculations and molecular dynamics modelling. Biologically, the substance was investigated for its cytotoxicity as well as in vitro (on Capan-2 and SK-MEL-1 cell lines) and in vivo (transplantable Ehrlich ascites carcinoma model) therapeutic activity.

Publication DOI: https://doi.org/10.1016/j.molliq.2022.119043
Funding Information: The work was supported by Russian Foundation for Basic Research (project number 21-515-10007). The equipment of the following Resource Centres of the Research Park of Saint Petersburg State University was used: Resource Centre ‘GeoModel’, the Centre for D
Additional Information: © 2022 Elsevier B.V. This accepted manuscript version is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International https://creativecommons.org/licenses/by-nc-nd/4.0/ Funding Information: The work was supported by Russian Foundation for Basic Research (project number 21-515-10007).
Uncontrolled Keywords: Cytostatic Agent,Cytotoxicity,Ehrlich ascites carcinoma,Electronic structure,Molecular Dynamics,Solutions,Electronic, Optical and Magnetic Materials,Atomic and Molecular Physics, and Optics,Condensed Matter Physics,Spectroscopy,Physical and Theoretical Chemistry,Materials Chemistry
Publication ISSN: 1873-3166
Last Modified: 10 Jun 2024 07:42
Date Deposited: 27 Apr 2022 15:59
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://www.sci ... 5815?via%3Dihub (Publisher URL)
PURE Output Type: Article
Published Date: 2022-06-15
Published Online Date: 2022-03-31
Accepted Date: 2022-03-27
Authors: Mikolaichuk, Olga V.
Popova, Elena A.
Protas, Alexandra V.
Rakipov, Ilnaz T.
Nerukh, Dmitry A. (ORCID Profile 0000-0001-9005-9919)
Petrov, Andrey V.
Charykov, Nikolay A.
Ageev, Sergei V.
Tochilnikov, Grigorii V.
Zmitrichenko, Iulia G.
Stukov, Aleksandr N.
Semenov, Konstantin N.
Sharoyko, Vladimir V.

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