Redesigning the Management and Treatment Algorithm For Dry Eye Clinicians


Dry eye disease multifactorial aetiologies and complexity makes a single treatment not functional enough to manage different subtypes. Instead, a tailored-managed-therapy plan is needed to lead to an effective treatment of signs and symptoms. An organisation tool to manage dry eye disease was created in 2017 by Tear Film & Ocular Surface Society Dry Eye WorkShop II, yet no differentiation between disease subtype (evaporative dry eye or aqueous dry eye) or severity, was made as a cause of lack of level 1 studies. This thesis sought to compile a series of experimental studies to provide; Additional scientific evidence of management strategies (Chapter 1:), by the means of; identifying therapeutic effects from all different treatment stages (Chapter 2:), assessing if further modifications of this guideline are needed (Chapter 3:) and to disseminate the current prescribing patterns of therapies across the globe (Chapter 4:). Accordingly, this thesis has found that: • Dry eye is being managed worldwide similarly to TFOS DEWS II recommendations, with exception of home-made facecloths. Products prescribed for evaporative dry eye and aqueous dry eye are different. North American and Asia/Middle Eastern regions tend to use a more pharmacological approach at lower levels of dry eye disease severity. • Between liposomal drops, liposomal sprays and emulsion-drops, the decrease in symptomatology was similar, no statistically significant changes happened to homeostatic markers during a 2-week treatment. • Only lipid-based artificial tear provides relief for patients with the evaporative subtype of dry eye, and both lipid-based and a non-lipid based artificial tears, show a 1-month symptomatology decrease for both dry eye subtypes, with signs taking 3-4 months to show a statistically significant improvement. • The use of an automatic massaging-mask provides improvement in symptomatology (subjectively improving severity) after 2 weeks of mask-treatment twice a day. • Eyelid warming therapy, improves Meibomian gland expression quality, regardless of its dropout extent. Debridement helps removing orifice obstruction in patients with Meibomian gland dropout, yet forcible expression provides nonadditional benefit on partial MGs.

Divisions: College of Health & Life Sciences > School of Optometry > Optometry
Additional Information: © Sònia Travé Huarte, 2021. Sònia Travé Huarte asserts her moral right to be identified as the author of this thesis. This copy of the thesis has been supplied on condition that anyone who consults it is understood to recognise that its copyright rests with its author and that no quotation from the thesis and no information derived from it may be published without appropriate permission or acknowledgement. If you have discovered material in Aston Publications Explorer which is unlawful e.g. breaches copyright, (either yours or that of a third party) or any other law, including but not limited to those relating to patent, trademark, confidentiality, data protection, obscenity, defamation, libel, then please read our Takedown Policy and contact the service immediately.
Institution: Aston University
Uncontrolled Keywords: dry eye disease,algorithm,management,therapy,treatment,artificial tears,eye mask,meibomian gland dysfunction,cardiovascular health,eye care practitioners
Last Modified: 08 Dec 2023 08:59
Date Deposited: 25 Apr 2022 17:02
Completed Date: 2021-09
Authors: Travé Huarte, Sònia (ORCID Profile 0000-0001-5604-0042)

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