Synthesis and characterization of semi-IPN hydrogels composed of sodium 2-acrylamido-2-methylpropanesulfonate and poly(ε-caprolactone) diol for controlled drug delivery

Abstract

Semi-interpenetrating polymer network (semi-IPN) hydrogel of sodium 2-acrylamido-2-methylpropane sulfonate (Na-AMPS) and poly(ε-caprolactone) (PCL) diol for drug delivery applications was synthesized via free radical UV-photopolymerization technique using 2-hydroxy-4′-(2-hydroxyethoxy)-2-methylpropiophenone as an initiator and poly(ethylene glycol) diacrylate (PEGDA) as a crosslinker. The hydrogels' chemical structure and internal morphology have been explored using Fourier-transform infrared spectroscopy and scanning electron microscopy. The influence of PCL diol and PEGDA concentrations on the synthesized semi-IPN hydrogel properties was investigated. The semi-IPN hydrogel can increase the elasticity of the hydrogel while simultaneously providing enough water uptake and water retention. Furthermore, the semi-IPN hydrogel was non-cytotoxic to mouse fibroblasts L929 cells. Finally, ciprofloxacin (CIP) was used as a model drug and was efficiently encapsulated into the semi-IPN hydrogels. Drug loading capacity was enhanced with increasing PCL diol and CIP content. It was also observed that the PCL diol and CIP contents had a marked influence on the release profiles. Thus, the rate of release could be designed by changing the Na-AMPS to PCL diol ratio and CIP content. Drug release was found to be both diffusion and swelling-controlled in accordance with the Fickian and non-Fickian transport mechanisms. In the light of the results obtained, their easy formability, their appropriate mechanical and physical properties make P(Na-AMPS)/PCL diol semi-IPN hydrogels are the potential candidates for use as drug carrier and controlled drug release materials in the biomedical field.

Publication DOI: https://doi.org/10.1016/j.eurpolymj.2021.110978
Divisions: College of Engineering & Physical Sciences > School of Infrastructure and Sustainable Engineering > Chemical Engineering & Applied Chemistry
College of Engineering & Physical Sciences
Additional Information: © 2021, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ Funding Information: This research project was supported by Fundamental Fund 2022, Chiang Mai University and has received partial funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 871650 (MEDIPOL). The authors would also like to thank Chiang Mai University and the Science Achievement Scholarship of Thailand (SAST). The raw/processed data required to reproduce these findings cannot be shared at this time as the data also forms part of an ongoing study.
Uncontrolled Keywords: Drug release,Poly(ε-caprolactone),Semi-interpenetrating polymer network (semi-IPN) hydrogel,Sodium 2-acrylamido-2-methylpropane sulfonate,Physics and Astronomy(all),Polymers and Plastics,Organic Chemistry,Materials Chemistry
Publication ISSN: 1873-1945
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://www.sci ... 7126?via%3Dihub (Publisher URL)
PURE Output Type: Article
Published Date: 2022-02-05
Published Online Date: 2021-12-29
Accepted Date: 2021-12-23
Authors: Rungrod, Amlika
Kapanya, Apichaya
Punyodom, Winita
Molloy, Robert
Mahomed, Anisa (ORCID Profile 0000-0002-3719-7543)
Somsunan, Runglawan

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Version: Accepted Version

Access Restriction: Restricted to Repository staff only until 29 June 2023.

License: Creative Commons Attribution Non-commercial No Derivatives


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