Antimicrobial Resistance and Comparative Genome Analysis of Klebsiella pneumoniae Strains Isolated in Egypt


Klebsiella pneumoniae is an important human pathogen in both developing and industrialised countries that can causes a variety of human infections, such as pneumonia, urinary tract infections and bacteremia. Like many Gram-negative bacteria, it is becoming resistant to many frontline antibiotics, such as carbapenem and cephalosporin antibiotics. In Egypt, K. pneumoniae is increasingly recognised as an emerging pathogen, with high levels of antibiotic resistance. However, few Egyptian K. pneumoniae strains have been sequenced and characterised. Hence, here, we present the genome sequence of a multidrug resistant K. pneumoniae strain, KPE16, which was isolated from a child in Assiut, Egypt. We report that it carries multiple antimicrobial resistance genes, including a blaNDM-1 carbapenemase and extended spectrum β-lactamase genes (i.e., blaSHV-40, blaTEM-1B, blaOXA-9 and blaCTX-M-15). By comparing this strain with other Egyptian isolates, we identified common plasmids, resistance genes and virulence determinants. Our analysis suggests that some of the resistance plasmids that we have identified are circulating in K. pneumoniae strains in Egypt, and are likely a source of antibiotic resistance throughout the world.

Publication DOI:
Divisions: College of Health & Life Sciences > School of Biosciences
Additional Information: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// 4.0/).
Publication ISSN: 2076-2607
Last Modified: 17 Jun 2024 17:27
Date Deposited: 13 Jan 2022 15:28
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Related URLs: https://www.mdp ... 6-2607/9/9/1880 (Publisher URL)
PURE Output Type: Article
Published Date: 2021-09-05
Accepted Date: 2021-09-01
Authors: Abdelwahab, Radwa
Alhammadi, Munirah M
Hassan, Ehsan A
Ahmed, Entsar H
Abu-Faddan, Nagla H
Daef, Enas A
Busby, Stephen J W
Browning, Douglas F (ORCID Profile 0000-0003-4672-3514)



Version: Published Version

License: Creative Commons Attribution

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