Insights into déjà vu:Associations between the frequency of experience and amplitudes of low-frequency oscillations in resting-state functional magnetic resonance imaging

Abstract

The phenomenon of déjà vu (DV) has intrigued scientists for decades, yet its neurophysiological underpinnings remain elusive. Brain regions have been identified in which morphometry differs between healthy individuals according to the frequency of their DV experiences. This study built upon these findings by assessing if and how neural activity in these and other brain regions also differ with respect to DV experience. Resting-state fMRI was performed on 68 healthy volunteers, 44 of whom reported DV experiences (DV group) and 24 who did not (NDV group). Using multivariate analyses, we then assessed the (fractional) amplitude of low-frequency fluctuations (fALFF/ALFF), a metric that is believed to index brain tissue excitability, for five discrete frequency bands within sets of brain regions implicated in DV and those comprising the default mode network (DMN). Analyses revealed significantly lower values of fALFF/ALFF for specific frequency bands in the DV relative to the NDV group, particularly within mesiotemporal structures, bilateral putamina, right caudatum, bilateral superior frontal cortices, left lateral parietal cortex, dorsal and ventral medial prefrontal cortex, and the posterior cingulate cortex. The pattern of differences in fALFF/ALFF measures between the brains of individuals who have experienced DV and those who have not provides new neurophysiological insights into this phenomenon, including the potential role of the DMN. We suggest that the erroneous feeling of familiarity arises from a temporary disruption of cortico-subcortical circuitry together with the upregulation of cortical excitability.

Publication DOI: https://doi.org/10.1111/ejn.15570
Divisions: College of Health & Life Sciences > School of Psychology
College of Health & Life Sciences > Aston Institute of Health & Neurodevelopment (AIHN)
College of Health & Life Sciences
Additional Information: This is the peer reviewed version of the following article: Zatloukalova, E., Mikl, M., Shaw, D. J., Marecek, R., Sakalosova, L., Kuratkova, M., Mitterova, K., Sklenarova, B., & Brazdil, M. (2021). Insights into déjà vu: Associations between the frequency of experience and amplitudes of low-frequency oscillations in resting-state functional magnetic resonance imaging. European Journal of Neuroscience, which has been published in final form at https://doi.org/10.1111/ejn.15570. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited
Uncontrolled Keywords: fALFF,Deja vu,Resting-State fMRI,Default Mode Network,ALFF,Neuroscience(all)
Publication ISSN: 1460-9568
Full Text Link:
Related URLs: https://onlinel ... .1111/ejn.15570 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2022-01
Published Online Date: 2021-12-14
Accepted Date: 2021-11-30
Submitted Date: 2021-04-13
Authors: Zatloukalova, Eva
Mikl, Michal
Shaw, Daniel Joel (ORCID Profile 0000-0003-1139-8301)
Marecek, Radek
Sakalosova, Lenka
Kuratkova, Marie
Mitterova, Kristyna
Sklenarova, Barbora
Brazdil, Milan

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Version: Accepted Version

Access Restriction: Restricted to Repository staff only until 14 December 2022.


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