Can Photothermal Post-Operative Cancer Treatment Be Induced by a Thermal Trigger?

Abstract

One of the current challenges in the post-operative treatment of breast cancer is to develop a local therapeutic vector for preventing recurrence and metastasis. Herein, we develop a core-shell fibrous scaffold comprising phase-change materials and photothermal/chemotherapy agents, as a thermal trigger for programmable-response drug release and synergistic treatment. The scaffold is obtained by in situ growth of a zeolitic imidazolate framework-8 (ZIF-8) shell on the surface of poly(butylene succinate)/lauric acid (PBS/LA) phase-change fibers (PCFs) to create PCF@ZIF-8. After optimizing the core-shell and phase transition behavior, gold nanorods (GNRs) and doxorubicin hydrochloride (DOX) co-loaded PCF@ZIF-8 scaffolds were shown to significantly enhance in vitro and in vivo anticancer efficacy. In a healthy tissue microenvironment at pH 7.4, the ZIF-8 shell ensures the sustained release of DOX. If the tumor recurs, the acidic microenvironment induces the decomposition of the ZIF-8 shell. Under the second near-infrared (NIR-II) laser treatment, GNR-induced thermal not only directly destroys the relapsed tumor cells but also accelerates DOX release by inducing the phase transition of LA. Our study sheds light on a well-designed programmable-response trigger, which provides a promising strategy for post-operative recurrence prevention of cancer.

Publication DOI: https://doi.org/10.1021/acsami.1c16283
Divisions: College of Engineering & Physical Sciences > Aston Institute of Materials Research (AIMR)
College of Engineering & Physical Sciences > Aston Institute of Urban Technology and the Environment (ASTUTE)
College of Engineering & Physical Sciences
College of Engineering & Physical Sciences > School of Infrastructure and Sustainable Engineering > Chemical Engineering & Applied Chemistry
Additional Information: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials and Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acsami.1c16283
Uncontrolled Keywords: core−shell fiber,photothermal-chemotherapy,post-operative cancer recurrence,electrospinning,phase-change fiber,programmable-response
Publication ISSN: 1944-8252
Full Text Link:
Related URLs: https://pubs.ac ... /acsami.1c16283 (Publisher URL)
PURE Output Type: Article
Published Date: 2021-12-29
Published Online Date: 2021-12-16
Accepted Date: 2021-12-10
Authors: Chen, Lei
Yu, Qianqian
Cheng, Kai
Topham, Paul D (ORCID Profile 0000-0003-4152-6976)
Xu, Mengmeng
Sun, Xiaoqing
Pan, Yumin
Jia, Yifan
Wang, Shuo
Wang, Linge

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Version: Accepted Version

Access Restriction: Restricted to Repository staff only until 16 December 2022.


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