Chen, Lei, Yu, Qianqian, Cheng, Kai, Topham, Paul D, Xu, Mengmeng, Sun, Xiaoqing, Pan, Yumin, Jia, Yifan, Wang, Shuo and Wang, Linge (2021). Can Photothermal Post-Operative Cancer Treatment Be Induced by a Thermal Trigger? ACS Applied Materials & Interfaces, 13 (51), pp. 60837-60851.
Abstract
One of the current challenges in the post-operative treatment of breast cancer is to develop a local therapeutic vector for preventing recurrence and metastasis. Herein, we develop a core-shell fibrous scaffold comprising phase-change materials and photothermal/chemotherapy agents, as a thermal trigger for programmable-response drug release and synergistic treatment. The scaffold is obtained by in situ growth of a zeolitic imidazolate framework-8 (ZIF-8) shell on the surface of poly(butylene succinate)/lauric acid (PBS/LA) phase-change fibers (PCFs) to create PCF@ZIF-8. After optimizing the core-shell and phase transition behavior, gold nanorods (GNRs) and doxorubicin hydrochloride (DOX) co-loaded PCF@ZIF-8 scaffolds were shown to significantly enhance in vitro and in vivo anticancer efficacy. In a healthy tissue microenvironment at pH 7.4, the ZIF-8 shell ensures the sustained release of DOX. If the tumor recurs, the acidic microenvironment induces the decomposition of the ZIF-8 shell. Under the second near-infrared (NIR-II) laser treatment, GNR-induced thermal not only directly destroys the relapsed tumor cells but also accelerates DOX release by inducing the phase transition of LA. Our study sheds light on a well-designed programmable-response trigger, which provides a promising strategy for post-operative recurrence prevention of cancer.
Publication DOI: | https://doi.org/10.1021/acsami.1c16283 |
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Divisions: | College of Engineering & Physical Sciences > Aston Institute of Materials Research (AIMR) College of Engineering & Physical Sciences > Aston Institute of Urban Technology and the Environment (ASTUTE) College of Engineering & Physical Sciences College of Engineering & Physical Sciences > School of Infrastructure and Sustainable Engineering > Chemical Engineering & Applied Chemistry College of Engineering & Physical Sciences > Aston Polymer Research Group Aston University (General) |
Additional Information: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials and Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acsami.1c16283 |
Uncontrolled Keywords: | core−shell fiber,photothermal-chemotherapy,post-operative cancer recurrence,electrospinning,phase-change fiber,programmable-response |
Publication ISSN: | 1944-8252 |
Last Modified: | 09 Dec 2024 08:43 |
Date Deposited: | 04 Jan 2022 12:19 |
Full Text Link: | |
Related URLs: |
https://pubs.ac ... /acsami.1c16283
(Publisher URL) |
PURE Output Type: | Article |
Published Date: | 2021-12-29 |
Published Online Date: | 2021-12-16 |
Accepted Date: | 2021-12-10 |
Authors: |
Chen, Lei
Yu, Qianqian Cheng, Kai Topham, Paul D ( 0000-0003-4152-6976) Xu, Mengmeng Sun, Xiaoqing Pan, Yumin Jia, Yifan Wang, Shuo Wang, Linge |