Emerging roles for AQP in mammalian extracellular vesicles

Abstract

Recent research in the aquaporin (AQP) field has identified a role for diverse AQPs in extracellular vesicles (EV). Though still in its infancy, there is a growing body of knowledge in the area; AQPs in EV have been suggested as biomarkers for disease, as drug targets and show potential as therapeutics. To advance further in this field, AQPs in EV must be better understood. Here we summarize current knowledge of the presence and function of AQPs in EV and hypothesise their roles in health and disease.

Publication DOI: https://doi.org/10.1016/j.bbamem.2021.183826
Divisions: College of Health & Life Sciences
College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences > School of Biosciences > Cellular and Molecular Biomedicine
College of Health & Life Sciences > Chronic and Communicable Conditions
Additional Information: This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/4.0) Funding: We thank the Biotechnology and Biological Sciences Research Council for their support (through BB/P025927/1 to Roslyn Bill and BB/S00324X/1 to Andrew Devitt).
Uncontrolled Keywords: Aquaporin,Exosome,Extracellular vesicle,Inflammation,Microvesicle,Oedema,Signalling,Water channel,Biophysics,Biochemistry,Cell Biology
Publication ISSN: 1879-2642
Last Modified: 15 May 2024 07:17
Date Deposited: 13 Dec 2021 09:11
Full Text Link: https://linking ... 005273621002741
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2022-03-01
Published Online Date: 2021-11-27
Accepted Date: 2021-11-19
Authors: Clarke-Bland, Charlotte E. (ORCID Profile 0000-0001-5776-2733)
Bill, Roslyn M. (ORCID Profile 0000-0003-1331-0852)
Devitt, Andrew (ORCID Profile 0000-0002-4651-6761)

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License: Creative Commons Attribution

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