Non-Alcoholic Fatty Liver Disease (NAFLD) and Potential Links to Depression, Anxiety, and Chronic Stress

Abstract

Non-alcoholic fatty liver disease (NAFLD) constitutes the most common liver disease worldwide, and is frequently linked to the metabolic syndrome. The latter represents a clustering of related cardio-metabolic components, which are often observed in patients with NAFLD and increase the risk of cardiovascular disease. Furthermore, growing evidence suggests a positive association between metabolic syndrome and certain mental health problems (e.g., depression, anxiety, and chronic stress). Given the strong overlap between metabolic syndrome and NAFLD, and the common underlying mechanisms that link the two conditions, it is probable that potentially bidirectional associations are also present between NAFLD and mental health comorbidity. The identification of such links is worthy of further investigation, as this can inform more targeted interventions for patients with NAFLD. Therefore, the present review discusses published evidence in relation to associations of depression, anxiety, stress, and impaired health-related quality of life with NAFLD and metabolic syndrome. Attention is also drawn to the complex nature of affective disorders and potential overlapping symptoms between such conditions and NAFLD, while a focus is also placed on the postulated mechanisms mediating associations between mental health and both NAFLD and metabolic syndrome. Relevant gaps/weaknesses of the available literature are also highlighted, together with future research directions that need to be further explored.

Publication DOI: https://doi.org/10.3390/biomedicines9111697
Divisions: College of Health & Life Sciences > School of Psychology
College of Health & Life Sciences
College of Health & Life Sciences > Aston Medical School
Additional Information: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Uncontrolled Keywords: non-alcoholic fatty liver disease,NAFLD,NASH,metabolic syndrome,insulin resistance,obesity,depression,anxiety,stress,health related quality of life
Publication ISSN: 2227-9059
Last Modified: 22 May 2024 07:17
Date Deposited: 18 Nov 2021 11:46
Full Text Link:
Related URLs: https://www.mdp ... -9059/9/11/1697 (Publisher URL)
PURE Output Type: Review article
Published Date: 2021-11-16
Accepted Date: 2021-11-13
Authors: Shea, Sue
Lionis, Christos
Kite, Chris
Atkinson, Lou (ORCID Profile 0000-0003-1613-3791)
Chaggar, Surinderjeet S.
Randeva, Harpal S.
Kyrou, Ioannis (ORCID Profile 0000-0002-6997-3439)

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