Protocol for a systematic review of the diagnostic test accuracy of tests for IgE-mediated food allergy

Abstract

Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of updating the guidelines on the diagnosis and management of food allergy. The existing guidelines are based on a systematic review of the literature until 30 September 2012. Therefore, a new systematic review must be undertaken to inform the new guidelines. This systematic review aims to assess the accuracy of index tests to support the diagnosis of IgE-mediated food allergy. Methods: The databases Cochrane CENTRAL (Trials), MEDLINE (OVID) and Embase (OVID) will be searched for diagnostic test accuracy studies from 1 October 2012 to 30 June 2021. Inclusion and exclusion criteria will be used to select appropriate studies. Data from these studies will be extracted and tabulated, and then reviewed for risk of bias and applicability using the QUADAS-2 tool. All evaluations will be done in duplicate. Studies with a high risk of bias and low applicability will be excluded. Meta-analysis will be performed if there are three or more studies of the same index test and food. Results: A protocol for the systematic review and meta-analyses is presented and was registered using Prospero prior to commencing the literature search. Discussion: Oral food challenges are the reference standard for diagnosis but involve considerable risks and resources. This protocol for systematic review aims to assess the accuracy of various tests to diagnose food allergy, which can be useful in both clinical and research settings.

Publication DOI: https://doi.org/10.1111/pai.13684
Divisions: College of Health & Life Sciences > School of Psychology
College of Health & Life Sciences > Applied Health Research Group
College of Health & Life Sciences
Additional Information: The submitted version available at 10.22541/au.162677307.71576556/v1 was accepted for publication on 9 Sept 2021. The final published version can be found at: Genuneit, J, Jayasinghe, S, Riggioni, C, et al; on behalf of the EAACI Food Allergy Guidelines Expert Group, the EAACI Research, Outreach Committee Food Allergy Group. Protocol for a systematic review of the diagnostic test accuracy of tests for IgE-mediated food allergy. Pediatr Allergy Immunol. 2021; 00: 1– 8. https://doi.org/10.1111/pai.13684
Uncontrolled Keywords: basophil activation test,component-resolved diagnostics,diagnosis,diagnostic tests,food allergy,IgE-mediated,mast cell activation test,skin prick test,specific IgE,Pediatrics, Perinatology, and Child Health,Immunology and Allergy,Immunology
Publication ISSN: 1399-3038
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2022-01
Published Online Date: 2021-10-21
Accepted Date: 2021-09-09
Authors: , the EAACI Food Allergy Guidelines Expert Group, the EAACI Resear
Genuneit, Jon
Jayasinghe, Sashini
Riggioni, Carmen
Peters, Rachel Louise
Chu, Derek K.
Munblit, Daniel
Boyle, Robert J.
Du Toit, George
Skypala, Isabel
Santos, Alexandra F.
Akdis, Cezmi A.
Alvarez-Perea, Alberto
Lozano, Montserrat Alvaro
Asero, Riccardo
Ballmer-Weber, Barbara
Barber, Domingo
Barni, Simona
Pajno, Giovanni Battista
Beyer, Kirsten
Bindslev-Jensen, Carsten
Brough, Helen
Buyuktiryaki, Betul
de Oliveira, Lucila Camargo Lopes
Cianferoni, Antonella
Chinthrajah, R. Sharon
Parker, Sean N.
Giacco, Stefano Del
DunnGalvin, Audrey
Eberlein, Bernadette
Ebisawa, Motohiro
Eigenmann, Philippe
Eiwegger, Thomas
Faber, Margaretha
Fernandez-Rivas, Montserrat
Feeney, Mary
Fisher, Helen
Giovannini, Mattia
Halken, Susanne
Hoffmann-Sommergruber, Karin
Jaumdally, Hannah
Jones, Christina J.
Knibb, Rebecca (ORCID Profile 0000-0001-5561-0904)
Knol, Edward
Konstantinou, George N.
Krawiec, Marta
Lau, Susanne
Mayorga, Lina
Marques-Mejias, M. Andreina
Meyer, Rosan
Moya, Beatriz

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