Genuneit, Jon, Jayasinghe, Sashini, Riggioni, Carmen, Peters, Rachel Louise, Chu, Derek K., Munblit, Daniel, Boyle, Robert J., Du Toit, George, Skypala, Isabel, Santos, Alexandra F., Akdis, Cezmi A., Alvarez-Perea, Alberto, Lozano, Montserrat Alvaro, Asero, Riccardo, Ballmer-Weber, Barbara, Barber, Domingo, Barni, Simona, Pajno, Giovanni Battista, Beyer, Kirsten, Bindslev-Jensen, Carsten, Brough, Helen, Buyuktiryaki, Betul, de Oliveira, Lucila Camargo Lopes, Cianferoni, Antonella, Chinthrajah, R. Sharon, Parker, Sean N., Giacco, Stefano Del, DunnGalvin, Audrey, Eberlein, Bernadette, Ebisawa, Motohiro, Eigenmann, Philippe, Eiwegger, Thomas, Faber, Margaretha, Fernandez-Rivas, Montserrat, Feeney, Mary, Fisher, Helen, Giovannini, Mattia, Halken, Susanne, Hoffmann-Sommergruber, Karin, Jaumdally, Hannah, Jones, Christina J., Knibb, Rebecca, Knol, Edward, Konstantinou, George N., Krawiec, Marta, Lau, Susanne, Mayorga, Lina, Marques-Mejias, M. Andreina, Meyer, Rosan, Moya, Beatriz and the EAACI Food Allergy Guidelines Expert Group, the EAACI Resear (2022). Protocol for a systematic review of the diagnostic test accuracy of tests for IgE-mediated food allergy. Pediatric Allergy and Immunology, 33 (1),
Abstract
Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of updating the guidelines on the diagnosis and management of food allergy. The existing guidelines are based on a systematic review of the literature until 30 September 2012. Therefore, a new systematic review must be undertaken to inform the new guidelines. This systematic review aims to assess the accuracy of index tests to support the diagnosis of IgE-mediated food allergy. Methods: The databases Cochrane CENTRAL (Trials), MEDLINE (OVID) and Embase (OVID) will be searched for diagnostic test accuracy studies from 1 October 2012 to 30 June 2021. Inclusion and exclusion criteria will be used to select appropriate studies. Data from these studies will be extracted and tabulated, and then reviewed for risk of bias and applicability using the QUADAS-2 tool. All evaluations will be done in duplicate. Studies with a high risk of bias and low applicability will be excluded. Meta-analysis will be performed if there are three or more studies of the same index test and food. Results: A protocol for the systematic review and meta-analyses is presented and was registered using Prospero prior to commencing the literature search. Discussion: Oral food challenges are the reference standard for diagnosis but involve considerable risks and resources. This protocol for systematic review aims to assess the accuracy of various tests to diagnose food allergy, which can be useful in both clinical and research settings.
| Publication DOI: | https://doi.org/10.1111/pai.13684 |
|---|---|
| Divisions: | College of Health & Life Sciences > School of Psychology College of Health & Life Sciences |
| Additional Information: | The submitted version available at 10.22541/au.162677307.71576556/v1 was accepted for publication on 9 Sept 2021. The final published version can be found at: Genuneit, J, Jayasinghe, S, Riggioni, C, et al; on behalf of the EAACI Food Allergy Guidelines Expert Group, the EAACI Research, Outreach Committee Food Allergy Group. Protocol for a systematic review of the diagnostic test accuracy of tests for IgE-mediated food allergy. Pediatr Allergy Immunol. 2021; 00: 1– 8. https://doi.org/10.1111/pai.13684 |
| Uncontrolled Keywords: | basophil activation test,component-resolved diagnostics,diagnosis,diagnostic tests,food allergy,IgE-mediated,mast cell activation test,skin prick test,specific IgE,Pediatrics, Perinatology, and Child Health,Immunology and Allergy,Immunology |
| Publication ISSN: | 1399-3038 |
| Last Modified: | 16 Dec 2024 08:34 |
| Date Deposited: | 15 Nov 2021 15:43 |
| Full Text Link: | |
| Related URLs: |
http://www.scop ... tnerID=8YFLogxK
(Scopus URL) |
PURE Output Type: | Article |
| Published Date: | 2022-01 |
| Published Online Date: | 2021-10-21 |
| Accepted Date: | 2021-09-09 |
| Authors: |
Genuneit, Jon
Jayasinghe, Sashini Riggioni, Carmen Peters, Rachel Louise Chu, Derek K. Munblit, Daniel Boyle, Robert J. Du Toit, George Skypala, Isabel Santos, Alexandra F. Akdis, Cezmi A. Alvarez-Perea, Alberto Lozano, Montserrat Alvaro Asero, Riccardo Ballmer-Weber, Barbara Barber, Domingo Barni, Simona Pajno, Giovanni Battista Beyer, Kirsten Bindslev-Jensen, Carsten Brough, Helen Buyuktiryaki, Betul de Oliveira, Lucila Camargo Lopes Cianferoni, Antonella Chinthrajah, R. Sharon Parker, Sean N. Giacco, Stefano Del DunnGalvin, Audrey Eberlein, Bernadette Ebisawa, Motohiro Eigenmann, Philippe Eiwegger, Thomas Faber, Margaretha Fernandez-Rivas, Montserrat Feeney, Mary Fisher, Helen Giovannini, Mattia Halken, Susanne Hoffmann-Sommergruber, Karin Jaumdally, Hannah Jones, Christina J. Knibb, Rebecca ( 
0000-0001-5561-0904)
Knol, Edward Konstantinou, George N. Krawiec, Marta Lau, Susanne Mayorga, Lina Marques-Mejias, M. Andreina Meyer, Rosan Moya, Beatriz , the EAACI Food Allergy Guidelines Expert Group, the EAACI Resear |
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)