A Systematic Review to Assess the Impact of Hyperbaric Oxygen Therapy on Glycaemia in People with Diabetes Mellitus


Background and Objectives: Hyperbaric oxygen is a recognised treatment for a range of medical conditions, including treatment of diabetic foot disease. A number of studies have reported an impact of hyperbaric oxygen treatment on glycaemic control in patients undergoing treatment for diabetic foot disease. There has been no systematic review considering the impact of hyperbaric oxygen on glycaemia in people with diabetes. Materials and Methods: A prospectively PROSPERO-registered (PROSPERO registration: CRD42021255528) systematic review of eligible studies published in English in the PUBMED, MEDLINE, and EMBASE databases, based on the following search terms: hyperbaric oxygen therapy, HBO2, hyperbaric oxygenation, glycaemic control, diabetes, diabetes Mellitus, diabetic, HbA1c. Data extraction to pre-determined piloted data collection form, with individual assessment of bias. Results: In total, 10 eligible publications were identified after screening. Of these, six articles reported a statistically significant reduction in blood glucose from hyperbaric oxygen treatment, while two articles reported a statistically significant increase in peripheral insulin sensitivity. Two articles also identified a statistically significant reduction in HbA1c following hyperbaric oxygen treatment. Conclusions: There is emerging evidence suggesting a reduction in glycaemia following hyperbaric oxygen treatment in patients with diabetes mellitus, but the existing studies are in relatively small cohorts and potentially underpowered. Additional large prospective clinical trials are required to understand the precise impact of hyperbaric oxygen treatment on glycaemia for people with diabetes mellitus.

Publication DOI: https://doi.org/10.3390/medicina57101134
Divisions: College of Health & Life Sciences > Aston Medical School
Additional Information: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Uncontrolled Keywords: diabetes,hyperbaric oxygen therapy,glycaemia
Publication ISSN: 1648-9144
Last Modified: 23 Apr 2024 16:45
Date Deposited: 22 Oct 2021 13:03
Full Text Link:
Related URLs: https://www.mdp ... 9144/57/10/1134 (Publisher URL)
PURE Output Type: Review article
Published Date: 2021-10-19
Accepted Date: 2021-10-16
Authors: Baitule, Sudhanshu
Patel, Aaran H.
Murthy, Narasimha
Sankar, Sailesh
Kyrou, Ioannis (ORCID Profile 0000-0002-6997-3439)
Ali, Asad
Randeva, Harpal S.
Robbins, Tim



Version: Published Version

License: Creative Commons Attribution

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