Sensitivity adjustable biosensor based on graphene oxide coated excessively tilted fiber grating


Biosensors play a significant role in biomedical, clinical and disease diagnosis areas. Here, we proposed Langmuir adsorption model to explain sensing mechanism of biosensor based on excessively tilted fiber grating (Ex-TFG) functionalized with graphene oxide (GO). Due to GO containing plenty of six-membered rings and oxygen-containing groups, the biomolecules can be easily adsorbed through π-π interaction and hydrogen bond. The whole interaction process obeys the Langmuir adsorption model in which there always an equilibrium during detecting process, inducing the sensor with adjustable bio-sensitivity and detection range. Three biosensors based on Ex-TFG coated with three different amount of GO were investigated for hemoglobin (Hb) detection experiment, showing pronounced bio-interaction induced resonance shifts. The experiment results indicate that GO coating could enhance the surface biological activity of Ex-TFG, making the Ex-TFG sensitive to the Hb biomolecule solutions. The three GO coated Ex-TFG sensors have the bio-sensitivity of 3.83 nm/(mg/ml), 4.33 nm/(mg/ml), and 8.21 nm/(mg/ml), and the detection range of 0.8 mg/ml, 0.6 mg/ml and 0.4 mg/ml, respectively, which are in good agreement with the prediction from the Langmuir adsorption model. By controlling the amount of the bio-functionalized materials, the bio-sensitivity and detection range of the Ex-TFG based biosensors can be easily adjusted.

Publication DOI:
Divisions: College of Engineering & Physical Sciences
Additional Information: © 2021, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Funding: This work was supported in part by National Natural Science Foundation of China (No. 62075071) and in part by the National Science Fund for Excellent Young Scholars (No. 61922033).
Uncontrolled Keywords: Dynamic detection range,Graphene oxide,Langmuir adsorption,Selectable sensitivity,Electronic, Optical and Magnetic Materials,Instrumentation,Condensed Matter Physics,Surfaces, Coatings and Films,Metals and Alloys,Electrical and Electronic Engineering,Materials Chemistry
Publication ISSN: 0925-4005
Full Text Link:
Related URLs: https://www.sci ... 925400521014003 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2022-01-15
Published Online Date: 2021-10-12
Accepted Date: 2021-09-24
Authors: Sun, Yuezhen
Guo, Xiaoxia
Moreno, Yarien
Sun, Qizhen
Yan, Zhijun
Zhang, Lin (ORCID Profile 0000-0002-1691-5577)



Version: Accepted Version

Access Restriction: Restricted to Repository staff only until 12 October 2022.

License: Creative Commons Attribution Non-commercial No Derivatives

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