THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

Abstract

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15539. Ion channels are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein‐coupled receptors, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

Publication DOI: https://doi.org/10.1111/bph.15539
Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences > School of Biosciences > Cellular and Molecular Biomedicine
College of Health & Life Sciences
Additional Information: © 2021 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of The British Pharmacological Society This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords: THE CONCISE GUIDE TO PHARMACOLOGY 2021/22
Publication ISSN: 1476-5381
Last Modified: 20 Feb 2024 08:18
Date Deposited: 17 Sep 2021 07:14
Full Text Link:
Related URLs: https://bpspubs ... .1111/bph.15539 (Publisher URL)
PURE Output Type: Article
Published Date: 2021-10
Published Online Date: 2021-09-16
Accepted Date: 2021-09-01
Authors: Alexander, Stephen PH
Mathie, Alistair
Peters, John A
Veale, Emma L
Striessnig, Jörg
Kelly, Eamonn
Armstrong, Jane F
Faccenda, Elena
Harding, Simon D
Pawson, Adam J
Southan, Christopher
Davies, Jamie A
Aldrich, Richard W.
Attali, Bernard
Baggetta, Austin M
Becirovic, Elvir
Biel, Martin
Bill, Roslyn M. (ORCID Profile 0000-0003-1331-0852)
Catterall, William A.
Conner, Alex C.
Davies, Paul
Delling, Markus
Virgilio, Francesco Di
Falzoni, Simonetta
Fenske, Stefanie
George, Chandy
Goldstein, Steve A. N.
Grissmer, Stephan
Ha, Kotdaji
Hammelmann, Verena
Hanukoglu, Israel
Jarvis, Mike
Jensen, Anders A.
Kaczmarek, Leonard K.
Kellenberger, Stephan
Kennedy, Charles
King, Brian
Kitchen, Philip (ORCID Profile 0000-0002-1558-4673)
Lynch, Joseph W.
Perez‐Reyes, Edward
Plant, Leigh D.
Rash, Lachlan
Ren, Dejian
Salman, Mootaz M.
Sivilotti, Lucia G.
Smart, Trevor G.
Snutch, Terrance P.
Tian, Jinbin
Trimmer, James S.
Van den Eynde, Charlotte
Vriens, Joris
Wei, Aguan D.
Winn, Brenda T.
Wulff, Heike
Xu, Haoxing
Yue, Lixia
Zhang, Xiaoli
Zhu, Michael

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