Wright, Sukhvir K., Wassmer, Evangeline and Vincent, Angela (2021). Pathogenic antibodies to AQP4:Neuromyelitis optica spectrum disorder (NMOSD). BBA -Biomembranes, 1863 (12),
Abstract
NMOSD is a rare but severe relapsing remitting demyelinating disease that affects both adults and children. Most patients have pathogenic antibodies that target the central nervous system AQP4 protein. This review provides an update on our current understanding of the disease pathophysiology and describes the clinical, paraclinical features and therapeutic management of the disease.
| Publication DOI: | https://doi.org/10.1016/j.bbamem.2021.183772 |
|---|---|
| Divisions: | College of Health & Life Sciences > Aston Pharmacy School College of Health & Life Sciences > Aston Institute of Health & Neurodevelopment (AIHN) College of Health & Life Sciences |
| Additional Information: | © 2021, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ Funding: SKW was funded by a Wellcome Trust Clinical Research Career Development Fellowship (216613/Z/19/Z) during this work. |
| Uncontrolled Keywords: | AQP4,Immunotherapy,MOGAD,NMOSD,Neuroinflammation,Neuronal antibodies,Biophysics,Biochemistry,Cell Biology |
| Publication ISSN: | 1879-2642 |
| Last Modified: | 16 Apr 2024 07:35 |
| Date Deposited: | 09 Sep 2021 15:45 |
| Full Text Link: | |
| Related URLs: |
https://linking ... 005273621002200
(Publisher URL) http://www.scop ... tnerID=8YFLogxK (Scopus URL) |
PURE Output Type: | Review article |
| Published Date: | 2021-12-01 |
| Published Online Date: | 2021-09-09 |
| Accepted Date: | 2021-09-03 |
| Authors: |
Wright, Sukhvir K.
(
0000-0002-5464-3779)
Wassmer, Evangeline Vincent, Angela |
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License: Creative Commons Attribution Non-commercial No Derivatives
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