Pathogenic antibodies to AQP4:Neuromyelitis optica spectrum disorder (NMOSD)

Abstract

NMOSD is a rare but severe relapsing remitting demyelinating disease that affects both adults and children. Most patients have pathogenic antibodies that target the central nervous system AQP4 protein. This review provides an update on our current understanding of the disease pathophysiology and describes the clinical, paraclinical features and therapeutic management of the disease.

Publication DOI: https://doi.org/10.1016/j.bbamem.2021.183772
Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences > Aston Brain Centre
College of Health & Life Sciences
Additional Information: © 2021, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ Funding: SKW was funded by a Wellcome Trust Clinical Research Career Development Fellowship (216613/Z/19/Z) during this work.
Uncontrolled Keywords: AQP4,Immunotherapy,MOGAD,NMOSD,Neuroinflammation,Neuronal antibodies,Biophysics,Biochemistry,Cell Biology
Full Text Link:
Related URLs: https://linking ... 005273621002200 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Review article
Published Date: 2021-12-01
Published Online Date: 2021-09-09
Accepted Date: 2021-09-03
Authors: Wright, Sukhvir K. (ORCID Profile 0000-0002-5464-3779)
Wassmer, Evangeline
Vincent, Angela

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Version: Accepted Version

Access Restriction: Restricted to Repository staff only until 9 September 2022.

License: Creative Commons Attribution Non-commercial No Derivatives


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