Semyachkina-Glushkovskaya, Oxana, Fedosov, Ivan, Shirokov, Alexander, Vodovozova, Elena, Alekseeva, Anna, Khorovodov, Alexandr, Blokhina, Inna, Terskov, Andrey, Mamedova, Aysel, Klimova, Maria, Dubrovsky, Alexander, Ageev, Vasily, Agranovich, Ilana, Vinnik, Valeria, Tsven, Anna, Sokolovski, Sergey, Rafailov, Edik, Penzel, Thomas and Kurths, Jürgen (2021). Photomodulation of lymphatic delivery of liposomes to the brain bypassing the blood-brain barrier: new perspectives for glioma therapy. Nanophotonics, 10 (12), pp. 3215-3227.
Abstract
The blood-brain barrier (BBB) has a significant contribution to the protection of the central nervous system (CNS). However, it also limits the brain drug delivery and thereby complicates the treatment of CNS diseases. The development of safe methods for an effective delivery of medications and nanocarriers to the brain can be a revolutionary step in the overcoming this limitation. Here, we report the unique properties of the lymphatic system to deliver tracers and liposomes to the brain meninges, brain tissues, and glioma in rats. Using a quantum-dot-based 1267 nm laser (for photosensitizer-free generation of singlet oxygen), we clearly demonstrate photostimulation of lymphatic delivery of liposomes to glioma as well as lymphatic clearance of liposomes from the brain. These pilot findings open promising perspectives for photomodulation of lymphatic delivery of drugs and nanocarriers to the brain pathology bypassing the BBB. The lymphatic "smart"delivery of liposomes with antitumor drugs in the new brain tumor branches might be a breakthrough strategy for the therapy of gliomas.
| Publication DOI: | https://doi.org/10.1515/nanoph-2021-0212 |
|---|---|
| Divisions: | College of Engineering & Physical Sciences > Aston Institute of Photonics Technology (AIPT) College of Engineering & Physical Sciences |
| Additional Information: | © 2021 Oxana Semyachkina-Glushkovskaya et al., published by De Gruyter. This work is licensed under the Creative Commons Attribution 4.0 International License. Funding: S.-G.O., I.V., A.K., I.B., A.T., A.M., M.K., A.D., V.A., I.A., V.V., A.T., T.P., and J.K. were supported by RF Governmental Grant № 075-15-2019-1885, Grant from RSF № 20-15-00090 and 19-15-00201, Grant from RFBR 19- 515-55016 China a, 20-015-00308-a. E.R. and S.S. gratefully acknowledge funding from EU’s H2020 FET OPEN NEUROPA project under Grant Agreement No. 863214. |
| Uncontrolled Keywords: | glioma,liposomes,lymphatic backroad to the brain,photostimulation,rats,Biotechnology,Electronic, Optical and Magnetic Materials,Atomic and Molecular Physics, and Optics,Electrical and Electronic Engineering |
| Publication ISSN: | 2192-8614 |
| Last Modified: | 23 Apr 2024 07:21 |
| Date Deposited: | 19 Jul 2021 09:00 |
| Full Text Link: | |
| Related URLs: |
https://www.deg ... -2021-0212/html
(Publisher URL) http://www.scop ... tnerID=8YFLogxK (Scopus URL) |
PURE Output Type: | Article |
| Published Date: | 2021-09-02 |
| Published Online Date: | 2021-07-08 |
| Accepted Date: | 2021-06-23 |
| Authors: |
Semyachkina-Glushkovskaya, Oxana
Fedosov, Ivan Shirokov, Alexander Vodovozova, Elena Alekseeva, Anna Khorovodov, Alexandr Blokhina, Inna Terskov, Andrey Mamedova, Aysel Klimova, Maria Dubrovsky, Alexander Ageev, Vasily Agranovich, Ilana Vinnik, Valeria Tsven, Anna Sokolovski, Sergey ( 
0000-0001-7445-7204)
Rafailov, Edik (
0000-0002-4152-0120)
Penzel, Thomas Kurths, Jürgen |
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)